Influence of Recent Advances in Medical Management on Clinical Outcomes of Cirrhosis

Talwalkar, Jayant A .; Kamath, Patrick S.
November 2005
Mayo Clinic Proceedings;Nov2005, Vol. 80 Issue 11, p1501
Academic Journal
Cirrhosis and its disease-related complications are the 12th leading cause of mortality among US adults and are the 5th leading cause of death for individuals aged 45 to 54 years. Hospitalization costs for disease-related complications are estimated at $18,000 per episode of care, and 10% of admitted patients die. Despite these ominous findings, the survival rate of patients with cirrhosis has improved during the past 2 decades. This observation coincides with the conducting and reporting of high-quality randomized controlled trials and observational studies. Therefore, the improved prognosis in cirrhosis may be related to the effective translation of research findings to clinical practice for this patient population. Although explicit data to support this claim are not available, this article reviews the reported trends in clinical outcomes for patients with cirrhosis and the existence of evidence-based medical information that is available to care for these chronically ill patients.


Related Articles

  • Clinical Significance and Outcome of Nosocomial Acquisition of Spontaneous Bacterial Peritonitis in Patients with Liver Cirrhosis. Hae Suk Cheong; Cheol-In Kang; Lee, Jeong A.; Soo Youn Moon; Mi Kyong Joung; Doo Ryeon Chung; Kwang Cheol Koh; Nam Yong Lee; Jae-Hoon Song; Kyong Ran Peck // Clinical Infectious Diseases;5/1/2009, Vol. 48 Issue 9, p1230 

    Background. There have been few reports on the causes and treatment outcomes for nosocomial spontaneous bacterial peritonitis (SBP) in patients with liver cirrhosis. Methods. We performed a retrospective cohort study to compare the microbiological and clinical characteristics in nosocomial...

  • The performance of prognostic models as predictors of mortality in patients with acute decompensation of cirrhosis. Fayad, Leonardo; Narciío-Schiavon, Janaína Luz; Lazzarotto, César; Ronsoni, Marcelo Fernando; Wildner, Letícia Muraro; Bazzo, Maria Luiza; Schiavon, Leonardo de Lucca; Dantas-Corrêa, Esther Buzaglo // Annals of Hepatology: Official Journal of the Mexican Associatio;Jan/Feb2015, Vol. 14 Issue 1, p83 

    Background. Although several prognostic models have been proposed for cirrhotic patients listed for transplantation, the performance of these scores as predictors of mortality in patients admitted for acute decompensation of cirrhosis has not been satisfactorily investigated. Aims. To study...

  • IATROGENIC INCARCERATION OF UMBILICAL HERNIA IN CIRRHOTIC PATIENTS WITH ASCITES. Chu, Kent-Man; McCaughan, Geoffrey W. // American Journal of Gastroenterology;Nov1995, Vol. 90 Issue 11, p2058 

    Studies incarceration of umbilical hernias in four patients, precipitated by treatment of ascites. Information on four cirrhotic patients with history of incarcerated umbilical hernia related to treatment of ascites and requiring surgical intervention; Mortality rate associated with umbilical...

  • Prediction of Post-operative Mortality in Patients with HCV-related Cirrhosis Undergoing Non-Hepatic Surgeries. HEMIDA, KHALID; SWAFF, REHAM EZZAT A. L.; SHABANA, SHERIF SADEK; ALI-ELDIN, FATMA; SAID, HANI // Journal of Clinical & Diagnostic Research;Oct2016, Vol. 10 Issue 10, p18 

    Introduction: Patients with chronic liver diseases are at great risk for both morbidity and mortality during the post-operative period due to the stress of surgery and the effects of general anaesthesia. Aim: The main aim of this study was to evaluate the value of Model for End-stage Liver...

  • Gallstones in Chronic Liver Disease Silva, Michael Anthony; Wong, Terence // Journal of Gastrointestinal Surgery;May2005, Vol. 9 Issue 5, p739 

    Gallstones occur more commonly in patients with cirrhosis. The incidence increases with severity of liver disease, and the majority remain asymptomatic. When symptoms do occur, morbidity and mortality are much higher than in noncirrhotic patients. Asymptomatic gallstones in cirrhotic patients...

  • Group B streptococcal bacteremia in non-pregnant adults: results from two Korean centers. Park, S.; Park, Y.; Chung, J.-W.; Huh, H.; Chae, S.; Kim, Y.; Lee, S. // European Journal of Clinical Microbiology & Infectious Diseases;Oct2014, Vol. 33 Issue 10, p1785 

    Patients with liver cirrhosis (LC) have impaired immunity and are, thus, predisposed to infection. Few studies have attempted to evaluate group B streptococcal (GBS) bacteremia in LC patients. A retrospective study of patients with GBS bacteremia was performed at the Dongguk University Ilsan...

  • Genetic variability of hepatitis B virus in Uruguay: D/F, A/F genotype recombinants. Lopez, L.; Flichman, D.; Mojsiejczuk, L.; Gonzalez, M.; Uriarte, R.; Campos, R.; Cristina, J.; Garcia-Aguirre, Laura // Archives of Virology;Sep2015, Vol. 160 Issue 9, p2209 

    Hepatitis B virus (HBV) infection is a serious global health problem. Approximately 2 billion people worldwide have been infected, and approximately 350 million individuals currently suffer from HBV-induced chronic liver infection, which causes 600,000 deaths annually from chronic hepatitis,...

  • Outcome of patients with cirrhosis requiring intensive care unit support: Prospective assessment of predictors of mortality. Singh, Nina; Gayowski, Timothy; Wagener, Marilyn M.; Marino, Ignazio R. // Journal of Gastroenterology;1998, Vol. 33 Issue 1, p73 

    Abstract: Determinants of outcome and the utility of the Child-Pugh score and the acute physiology and chronic health evaluation (APACHE) II score as predictors of outcome were prospectively assessed in 54 consecutive patients with cirrhosis requiring intensive care unit (ICU) management....

  • Can the MELD Score Predict Perioperative Morbidity for Patients with Liver Cirrhosis Undergoing Laparoscopic Cholecystectomy? Bingener, Juliane; Cox, Diane; Michalek, Joel; Mejia, Alejandro // American Surgeon;Feb2008, Vol. 74 Issue 2, p156 

    The Model for End Stage Liver Disease (MELD) score is a mortality predictor in patients awaiting liver transplantation. We evaluated the MELD score's ability to predict morbidity for patients with cirrhosis undergoing laparoscopic cholecystectomy. From March 1991 to February 2004, data of all...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics