TITLE

A2144G Is the Main Mutation in the 23S rRNA Gene of Helicobacter pylori Associated with Clarithromycin Resistance

AUTHOR(S)
Momynaliev, K.T.; Selezneva, O. V.; Kozlova, A. A.; Vereshchagin, V. A.; Il'ina, E. N.; Govorun, V. M.
PUB. DATE
October 2005
SOURCE
Russian Journal of Genetics;Oct2005, Vol. 41 Issue 10, p1095
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
To detect point mutations A2115C, A2143G/C, and A2144G in the 23S rRNA gene of Helicobacter pylori associated with resistance of the microorganism to clarithromycin, a new powerful way of analysis was used. This method involved the reaction of minisequencing followed by MALDI-TOF mass spectrometry of reaction products. In ten analyzed clarithromycin-resistant clinical isolates of H. pylori obtained in Russia, the resistance was found to be mediated only by mutation A2144G in the 23S rRNA gene.
ACCESSION #
18842929

 

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