TITLE

THE CURRENT STATUS OF SMALL BOWEL TRANSPLANTATION IN THE UK AND INTERNATIONALLY

AUTHOR(S)
Middleton, S. J.; Jamieson, N. V.
PUB. DATE
November 2005
SOURCE
Gut;Nov2005, Vol. 54 Issue 11, p1650
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The article focuses on intestinal transplantation for patients with intestinal failure and complications of parenteral nutrition. Small intestinal transplantation should now be routinely considered for patients with irreversible intestinal failure and complications of parenteral nutrition. Although technically possible for a century, and attempted in humans for more than 40 years, immunological graft intolerance presented an impenetrable barrier to successful engraftment until the development of the powerful calcineurin inhibitor immunosuppressive agents in the late 1970s. Their subsequent clinical use over the past 17 years has transformed small intestinal transplantation from a position of predictable failure to predominant success and routine clinical reality for a select group of patients.
ACCESSION #
18830616

 

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