Middleton, S. J.; Jamieson, N. V.
November 2005
Gut;Nov2005, Vol. 54 Issue 11, p1650
Academic Journal
The article focuses on intestinal transplantation for patients with intestinal failure and complications of parenteral nutrition. Small intestinal transplantation should now be routinely considered for patients with irreversible intestinal failure and complications of parenteral nutrition. Although technically possible for a century, and attempted in humans for more than 40 years, immunological graft intolerance presented an impenetrable barrier to successful engraftment until the development of the powerful calcineurin inhibitor immunosuppressive agents in the late 1970s. Their subsequent clinical use over the past 17 years has transformed small intestinal transplantation from a position of predictable failure to predominant success and routine clinical reality for a select group of patients.


Related Articles

  • Short Bowel Syndrome: Parenteral Nutrition Versus Intestinal Transplantation. Where Are We Today? Mark DeLegge; Mohammad Alsolaiman; English Barbour; Samah Bassas; M. Siddiqi; Nicole Moore // Digestive Diseases & Sciences;Apr2007, Vol. 52 Issue 4, p876 

    Abstract  Current management of short bowel syndrome (SBS) revolves around the use of home TPN (HPN). Complications include liver disease, catheter-related infections or occlusions, venous thrombosis, and bone disease. Patient survival with SBS on TPN is 86% and 75% at 2 and 5 years,...

  • Clinical outcome in patients from a single region who were dependent on parenteral nutrition for 28 days or more. Köglmeier, J.; Puntis, J. W. L. // Archives of Disease in Childhood;Apr2008, Vol. 93 Issue 4, p300 

    Background: The frequency and outcome of intestinal failure (IF) in children are not well defined in the UK. Long term parenteral nutrition (PN) is an effective intervention, with intestine transplantation offering the possibility of survival should life-threatening complications arise in those...

  • Complete Resolution of Severe Diarrhoea after Conversion from Mycophenolate Mofetil to Enteric-coated Mycophenolate Sodium (myfortic) in a Patient at High Immunological Risk. Breidenbach, Thomas; Spangenberg, Marcus; Nagel, Eckhard // Drugs;2006 Supplement, Vol. 66, p25 

    The article presents information on a case study in which a patient, who was treated with mycophenolate mofetil, developed diarrhea. The patient, who developed end-stage renal disease due to chronic glomerulonephritis, underwent a renal transplant. He was given immunosuppressive agents like...

  • Intestinal Malrotation In A 13 Year-Old Boy With Catastrophic Consequence: Case Report. Fernández, Eudaldo M. López-Tomassetti; Siverio, Norberto Hernandez; González, Iván Arteaga // Internet Journal of Pediatrics & Neonatology;2006, Vol. 6 Issue 1, p13 

    Intestinal transplantation has recently become an accepted therapy for selected patients with irreversible intestinal failure. A non-reconstructible gastrointestinal tract is also an indication for consideration of intestinal transplantation. We present the case of a 13-year-old boy who lost his...

  • Intestino corto: de la resección al trasplante. Rodríguez-Montes, José Antonio // Nutricion Hospitalaria;nov2014, Vol. 30 Issue 5, p961 

    Short bowel syndrome (SBS) is characterized by a significant reduction in the effective intestinal surface by an anatomical or functional loss of the small intestine. It mainly occurs after extensive bowel resection, intestinal intrinsic disease or surgical bypass. The main complications are...

  • Intestinal Failure -- An Indian Perspective. WADHWA, NISHANT; SIBAL, ANUPAM // Indian Pediatrics;Sep2008, Vol. 45 Issue 9, p741 

    The article focuses on the management of permanent intestinal failure (IF) in children. Parenteral nutrition (PN) is said to be an important foundation in the management of children with IF. It claims that the development of effective home-based PN program is important for the successful...

  • Permanent Intestinal Failure. GOULET, OLIVIER; FUSARO, FABIO; LACAILLE, FLORENCE; SAUVAT, FRÉDÉRIQUE // Indian Pediatrics;Sep2008, Vol. 45 Issue 9, p753 

    Context: Intestinal failure (IF) requires the use of parenteral nutrition as long as it persists and may be in case of persistence an indication for intestinal transplantation. Evidence acquisition: Literature search was performed both electronically and manually. Results and conclusions:...

  • Indicaciones, técnicas y resultados del trasplante de intestino delgado. Santamaría, M. López; Oliveros, F. Hernández // Nutricion Hospitalaria;may/jun2007 suppleme, Vol. 22, p113 

    The most recent outcomes on bowel transplantation (BT), with a survival rate immediately after transplant higher than 80% and a great rate of survivors achieving complete digestive autonomy and able to carry out activities according to their age allow for considering BT as the first choice...

  • The nutritional management of Australia's first intestinal transplant recipient - a case study. A. Hamilton, Kate; Chapman, Brooke // Transplant Journal of Australasia;Dec2012, Vol. 21 Issue 3, p22 

    An abstract describing the patient’s nutritional management and highlighting the positive outcomes of referral to a specialist service resulting in intestinal transplant is presented.


Read the Article


Sign out of this library

Other Topics