Following the TRAIL from hepatitis C virus and alcohol to fatty liver

Afford, S. C.; Adams, D. H.
November 2005
Gut;Nov2005, Vol. 54 Issue 11, p1518
Academic Journal
The article focuses on tumor necrosis factor related apoptosis inducing ligand as a novel mediator of fatty liver disease. Fatty liver or steatosis is a common finding in several liver diseases, most notably non-alcoholic fatty liver disease and alcoholic liver disease but is also seen more frequently in chronic hepatitis C virus related liver disease than would be predicted by simple concurrence of the two diseases. Several mechanisms have been proposed to explain why steatosis might develop in chronic viral infection, including direct effects of the virus on lipid metabolism, but none of these is entirely convincing.


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