TITLE

Surface-enhanced Raman scattering detection of lysophosphatidic acid

AUTHOR(S)
Seballos, Leo; Zhang, Jin Z.; Sutphen, Rebecca
PUB. DATE
November 2005
SOURCE
Analytical & Bioanalytical Chemistry;Nov2005, Vol. 383 Issue 5, p763
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Surface-enhanced Raman scattering using silver nanoparticles was applied to detect various forms of lysophosphatidic acid (LPA) to examine its potential application as an alternative to current detection methods of LPA as biomarkers of ovarian cancer. Enhancement of the Raman modes of the molecule, especially those related to the acyl chain within the 800–1300 cm−1 region, was observed. In particular, the C–C vibration mode of the gauche-bonded chain around 1100 cm−1 was enhanced to allow the discrimination of two similar LPA molecules. Given the molecular selectivity of this technique, the detection of LPA using SERS may eliminate the need for partial purification of samples prior to analysis in cancer screening.
ACCESSION #
18755139

 

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