TITLE

Structure elucidation of degradation products of the antibiotic drug amoxicillin

AUTHOR(S)
Nagele, Edgar; Moritz, Ralf
PUB. DATE
September 2005
SOURCE
Chemical Business;Sep2005, Vol. 19 Issue 9, p40
SOURCE TYPE
Trade Publication
DOC. TYPE
Article
ABSTRACT
Today, it is necessary to identify and confirm the identity of all compounds appearing in the process of the discovery and the development of a new drug substance in the pharmaceutical industry. In this Application Note the identification and confirmation of degradation products from a final dosage of the antibiotic drug amoxicillin obtained under stress conditions will be demonstrated by structure elucidation with LC ion trap MS/MS and MS. The identity confirmation of the degradation products by accurate mass measurement of the molecular ions and of the CID fragments by LC/ESI oaTOF will be discussed in Part II of this work.
ACCESSION #
18750031

 

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