Anti-HIV-1 Microbicides - 'Chemical Condoms' Designed to Limit the Scourge of the HIV-1 Pandemic

Scholand, Stephen J.; DeSimone, Joseph A.; Pomerantz, Roger J.
November 2005
Current Pharmaceutical Design;Nov2005, Vol. 11 Issue 29, p3747
Academic Journal
The HIV pandemic continues to spread throughout the world, particularly affecting populations in developing countries. Women now comprise half of those infected. Efforts to limit this scourge need to be maximally implemented. A multi-faceted approach, including the research and advance of microbicides - or 'chemical condoms' - offers promise. Microbicides are self-administered, prophylactic products designed to protect against sexually transmitted pathogens, including HIV-1. Important features include safety, efficacy and user acceptability. This review summarizes some of the important products in the development pipeline.


Related Articles

  • Perceptions of youth on the use of condoms for HIV prevention in Capricorn District, Limpopo Province, South Africa. MOTHIBA, T. M.; MAPUTLE, M. S.; LEBESE, R. T. // African Journal for Physical, Health Education, Recreation & Dan;Sep2012 Supplement 2, p13 

    Despite the fact that condoms are very effective against Sexually Transmitted Infections (STIs) and Human Immunodeficiency Virus transmission (HIV), many people who are at risk do not use them. Latex condoms provide an essentially impermeable barrier to particles the size of HIV and other STI...

  • Beyond our own backyard: World AIDS Day 2004. McElhose, John // Gay & Lesbian Times;11/25/2004, Issue 883, p40 

    Examines various aspects of AIDS and HIV around the world as the World AIDS Day 2004 is being marked. Worldwide statistics of HIV and AIDS; Diversity of the AIDS and HIV epidemic; High percent of new infections among African-American and Hispanic women; Role of drug firms in AIDS and HIV...

  • Estimating and projecting HIV prevalence and AIDS deaths in Tanzania using antenatal surveillance data. Somi, Geofrey R.; Matee, Mecky I. N.; Swai, Roland O.; Lyamuya, Eligius F.; Killewo, Japhet; Kwesigabo, Gideon; Tulli, Tuhuma; Kabalimu, Titus K.; Ng'ang'a, Lucy; Isingo, Raphael; Ndayongeje, Joel // BMC Public Health;2006, Vol. 6 Issue 1, p120 

    Background: The Estimations and Projections Package (EPP 2005) for HIV/AIDS estimates and projects HIV prevalence, number of people living with HIV and new HIV infections and AIDS cases using antenatal clinic (ANC) surveillance data. The prevalence projection produced by EPP can be transferred...

  • Sex workers, condoms, and mobility among men in Uzbekistan: implications for HIV transmission. Smolak, Alex; El-Bassel, Nabila; Malin, Anne; Terlikbayeva, Assel; Samatova, Salkynai // International Journal of STD & AIDS;Mar2016, Vol. 27 Issue 4, p268 

    Uzbekistan has one of the fastest growing HIV epidemics in the world. In this study, men who reported mobility were compared to non-mobile men in regard to paying for sex and condom use during paid sex. The sample included 2333 men between the ages of 15 and 59 in Uzbekistan. Generalised linear...

  • SEXUAL BEHAVIOUR AND PRACTICES: A STUDY OF MALE CLIENTS OF FEMALE SEX WORKERS IN MUMBAI. Singh, S. K.; Mondal, Sudipta; Sharma, Nidhi // Journal of Family Welfare;Dec2009, Vol. 55 Issue 2, p39 

    The article presents a study on the sexual behavior and practices of the male clients of female sex workers in Mumbai, India. It highlights the early stages of sexual debut and the experience of sex workers in engaging in sexual relationship with different partners. It provides the risk...

  • Knowledge of blood-borne transmission risk is inversely associated with HIV infection in sub-Saharan Africa. Brewer, Devon D. // Journal of Infection in Developing Countries;Mar2011, Vol. 5 Issue 3, p182 

    Introduction: Accurate, comprehensive knowledge of an infectious pathogen's modes of transmission helps people to avoid infection. Growing evidence suggests that blood-borne HIV transmission is widespread in sub-Saharan Africa. Methodology: I examined the association between knowledge of...

  • Microbicides gain visibility. K. T. // American Journal of Health-System Pharmacy;6/15/2006, Vol. 63 Issue 12, p1107 

    The article focuses on the attention given to the use of vaginal microbicides to prevent HIV infection in the developing countries. Microbicides are on clinical testing to assess its effectivity in disrupting the HIV bond to target cells, and as a fusion inhibitor. Furthermore, the demand for...

  • International Scientific Collaboration in HIV and HPV: A Network Analysis. Vanni, Tazio; Mesa-Frias, Marco; Sanchez-Garcia, Ruben; Roesler, Rafael; Schwartsmann, Gilberto; Goldani, Marcelo Z.; Foss, Anna M. // PLoS ONE;Mar2014, Vol. 9 Issue 3, p1 

    Research endeavours require the collaborative effort of an increasing number of individuals. International scientific collaborations are particularly important for HIV and HPV co-infection studies, since the burden of disease is rising in developing countries, but most experts and research funds...

  • Rapid and simple point of care diagnostics for STIs. Mabey, David; Peeling, Rosanna W.; Perkins, Mark D. // Sexually Transmitted Infections;Dec2001, Vol. 77 Issue 6, p397 

    The high prevalence of asymptomatic gonococcal and chlamydial infections is one of the greatest obstacles to sexually transmitted infections (STI) control, especially in developing countries, where partner notification is difficult. A widely available diagnostic test which allowed prompt and...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics