TITLE

A new mass spectrometry electrospray tip obtained via precise mechanical micromachining

AUTHOR(S)
Yan-Zin Chang; Mu-Wen Yang; Gou-Jen Wang
PUB. DATE
September 2005
SOURCE
Analytical & Bioanalytical Chemistry;Sep2005, Vol. 383 Issue 1, p76
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
A new electrospray tip incorporating a beveled edge has been designed for use in plastic electrophoresis chip/electrospray mass spectrometry. Theoretical hydrodynamic analysis has been conducted to model the analytical sensitivity of the spray tip shape. A larger sample wall, that provides increased hydraulic pressure, is recommended in order to preserve the fluid stability at the tip outlet. A polymer with better hydrophobic characteristics than glass was used for the spray tip in order to restrict moisture accumulation at the spray tip outlet. Experimental results demonstrate that the analytical sensitivity of the proposed scheme is better than that obtained using the flat-head tip. Although a tapered capillary tip is commonly used in electrophoresis chip/electrospray mass spectrometry, the proposed tip offers a similar sensitivity while being more rugged and durable than the conventional tapered capillary tip. The cost of our design is also much lower than conventional spray tips.
ACCESSION #
18674366

 

Related Articles

  • PREPARATION OF POLYURETHANE MICROSPHERES BY ELECTROSPRAY TECHNIQUE. Vlad, S.; Ciobanu, C.; Butnaru, M.; Macocinschi, D.; Filip, D.; Gradinaru, L. M.; Mandru, M. // Digest Journal of Nanomaterials & Biostructures (DJNB);Apr-Jun2011, Vol. 6 Issue 2, p643 

    In this paper some polyurethane membranes were prepare by electrospraying process to obtain biocompatible materials. The polyurethanes utilized in this study were synthesized from hexamethylene diisocyanate (HDI), polytetramethylene ether glycol (PTMEG) and butanediol (BD) filled with different...

  • Research on chemical composition changing of heteroatom compounds during asphalt aging process. ZHANG Hai-yan; LIANG Junlin; CAO Dong-wei; XIONG Jianping; HE Min; ZHANG Yan-jun; CHEN Yan-ju // Applied Mechanics & Materials;2014, Vol. 744-746, p1456 

    It's easy to cause asphalt aging in the production, storage, transportation and construction sectors; the polar compounds of asphalt in the aging process were studied by using negative-ion electrospray ionization (ESI) Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometry...

  • Derivatization for Ultratrace Quantitative Analysis Using HPLC-ESI-MS. Schug, Kevin A. // LC-GC North America;Apr2013, Vol. 31 Issue 4, p334 

    A blog related to the derivatization technique electrospray ionization (ESI) is presented.

  • Erratum to: Mechanical ion gate for electrospray-ionization ion-mobility spectrometry. Li Zhou; Collins, David C.; Lee, Edgar D.; Rockwood, Alan L.; Lee, Milton L. // Analytical & Bioanalytical Chemistry;Oct2010, Vol. 398 Issue 4, p1833 

    A correction to the article "Mechanical Ion Gate for Electrospray-Ionization Ion-Mobility Spectrometry" that was published in the online version of the journal on August 14, 2010 issue is presented.

  • Mass analysis of receptor?DNA complexes. DeWitt, Natalie // Nature Biotechnology;Dec99, Vol. 17 Issue 12, p1150 

    Focuses on the use of electrospray ionization mass spectrometry (ESI-MS) in the study of protein complexes. Use of ESI-MS in the analysis of the effect of ligands on heterodimerization of full-length vitamin D and retinoid X receptors.

  • Rapid identification and semi-quantitative determination of polymer additives by desorption electrospray ionization/time-of-flight mass spectrometry. Reiter, Silke M.; Buchberger, Wolfgang; Klampfl, Christian W. // Analytical & Bioanalytical Chemistry;Sep2011, Vol. 400 Issue 8, p2317 

    fast and simple method for the direct qualitative and semi-quantitative determination of a set of four polymer additives in plastic samples by desorption electrospray ionization time-of-flight mass spectrometry (DESI-TOF-MS) is presented. After evaluation of crucial DESI parameters such as...

  • Capillary electrophoresis-mass spectrometry using noncovalently coated capillaries for the analysis of biopharmaceuticals. Haselberg, R.; Brinks, V.; Hawe, A.; De Jong, G. J.; Somsen, G. W. // Analytical & Bioanalytical Chemistry;Jun2011, Vol. 400 Issue 1, p295 

    In this work, the usefulness of capillary electrophoresis-electrospray ionization time-of-flight-mass spectrometry for the analysis of biopharmaceuticals was studied. Noncovalently bound capillary coatings consisting of Polybrene-poly(vinyl sulfonic acid) or Polybrene-dextran sulfate-Polybrene...

  • Fast capillary electrophoresis-time-of-flight mass spectrometry using capillaries with inner diameters ranging from 75 to 5 μm. Grundmann, Marco; Matysik, Frank-Michael // Analytical & Bioanalytical Chemistry;Jun2011, Vol. 400 Issue 1, p269 

    Fast electrophoretic separations in fused silica capillaries (CE) coupled to time-of-flight mass spectrometry (TOF-MS) are presented. CE separations of the model analytes (epinephrine, norepinephrine, dopamine, histidine, and isoproterenol) under conditions of high electric field strengths of up...

  • The Application of LC-MS/MS Technology for Proteomic Analysis of Gingival Tissue: a Pilot Study. Badovinac, Ana; Razdorov, Genadij; Grgurević, Lovorka; Puhar, Ivan; Plančak, Darije; Božić, Darko // Acta Stomatologica Croatica;2013, Vol. 47 Issue 1, p10 

    Aim: The aim of this study was to find an optimal method to identify maximal number of proteins from human gingival tissue samples in a patient with aggressive periodontitis using label-free quantitative liquid chromatography mass spectrometry technology (LC-MS/MS), and to compare proteome of...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics