TITLE

Elevated Plasma Levels of Fibrin Degradation Products by Granulocyte-Derived Elastase in Patients with Disseminated Intravascular Coagulation

AUTHOR(S)
Matsumoto, Takeshi; Wada, Hideo; Nobori, Tsutomu; Nakatani, Kaname; Onishi, Katsuya; Nishikawa, Masakatsu; Shiku, Hiroshi; Kazahaya, Yumiko; Sawai, Tokio; Koike, Kaoru; Matsuda, Michio
PUB. DATE
October 2005
SOURCE
Clinical & Applied Thrombosis/Hemostasis;Oct2005, Vol. 11 Issue 4, p391
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Plasma levels of granulocyte-derived elastase (GE-XDP), D-dimer, and soluble fibrin (SF) were examined in 177 patients with disseminated intravascular coagulation (DIC) of various etiologies. Plasma levels of GE-XDP and D-dimer, but not SF, were significantly high in patients with sepsis and solid cancer. The ratio of GE-XDP/D-dimer was significantly high in patients with trauma, burn, and sepsis, suggesting that fibrinolysis due to GE-XDP may be dominant in Die, Plasma levels of GE-XDP and D-dimer, but not SF, were significantly high in patients with overt DIC and correlated with DIC score. Plasma levels of GE-XDP, but not SF, correlated significantly with D-dimer. Plasma levels of D-dimer, but not SF, correlated significantly with plasmin plasmin inhibitor complex (PPIC). Plasma levels of GE-XDP and D-dimer, but not SF, were significantly high in nonsurvivors. Plasma levels of GE-XDP, but not SF, correlated significantly with sepsis-related organ failure assessment (SOFA) score. These results suggest that GE-XDP is a potentially useful marker for the diagnosis of overt-DIC and as a predictor of organ failure-related outcome.
ACCESSION #
18656689

 

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