Elevated Plasma Levels of Fibrin Degradation Products by Granulocyte-Derived Elastase in Patients with Disseminated Intravascular Coagulation

Matsumoto, Takeshi; Wada, Hideo; Nobori, Tsutomu; Nakatani, Kaname; Onishi, Katsuya; Nishikawa, Masakatsu; Shiku, Hiroshi; Kazahaya, Yumiko; Sawai, Tokio; Koike, Kaoru; Matsuda, Michio
October 2005
Clinical & Applied Thrombosis/Hemostasis;Oct2005, Vol. 11 Issue 4, p391
Academic Journal
Plasma levels of granulocyte-derived elastase (GE-XDP), D-dimer, and soluble fibrin (SF) were examined in 177 patients with disseminated intravascular coagulation (DIC) of various etiologies. Plasma levels of GE-XDP and D-dimer, but not SF, were significantly high in patients with sepsis and solid cancer. The ratio of GE-XDP/D-dimer was significantly high in patients with trauma, burn, and sepsis, suggesting that fibrinolysis due to GE-XDP may be dominant in Die, Plasma levels of GE-XDP and D-dimer, but not SF, were significantly high in patients with overt DIC and correlated with DIC score. Plasma levels of GE-XDP, but not SF, correlated significantly with D-dimer. Plasma levels of D-dimer, but not SF, correlated significantly with plasmin plasmin inhibitor complex (PPIC). Plasma levels of GE-XDP and D-dimer, but not SF, were significantly high in nonsurvivors. Plasma levels of GE-XDP, but not SF, correlated significantly with sepsis-related organ failure assessment (SOFA) score. These results suggest that GE-XDP is a potentially useful marker for the diagnosis of overt-DIC and as a predictor of organ failure-related outcome.


Related Articles

  • Factor XIII deficiency (Fibrin stabilizing factor). Jim, Robert T. S. // Hawaii Medical Journal;Oct2008, Vol. 67 Issue 10, p270 

    Factor XIII defi ciency (Fibrin stabilizing Factor or FSF) is a rare coagulation defect. The only patient believed to have this disorder in Hawai'i is presented in this report.

  • Microvascular Alterations in Thrombin-Induced Experimental Disseminated Intravascular Coagulation in the Dog. Vignolo-Scalone, Washington H.; Vignolo-Puglia, Washington H.; Kitchens, Craig S. // Angiology;May1984, Vol. 35 Issue 5, p261 

    Disseminated intravascular coagulation is often characterized by organ failure and bleeding. By use of light microscopy, previous studies have shown extensive fibrin deposition in vessels. However, quantification of fibrin deposition using ultrastructural methods has not been reported. In this...


    The fluidity of the blood is maintained and safeguarded by (1) the relative slowness of thrombin generation in blood, and (2) the prompt removal of thrombin from circulating blood. The slowness of thrombin production is due in part to the absence of preformed thromboplastin in the blood, the...

  • Bleeding Mechanisms With Special Attention to Coagulation Disorders. Halldorsson, S.; Connelly, John P. // Clinical Pediatrics;Jan1968, Vol. 7 Issue 1, p34 

    The article discusses bleeding mechanisms focusing on coagulation disorders. The case of an adult male experiencing pain and swelling is reviewed revealing a diagnosis of thromboplastin inhibitory factor. The case offers a perspective on the three main mechanisms involved in the control of...

  • DIC.  // Taber's Cyclopedic Medical Dictionary (2009);2009, Issue 21, p643 

    A definition of the term "DIC," which means disseminated intravascular coagulation, is presented.

  • Disseminated Intravascular Coagulation: Objective Criteria for Clinical and Laboratory Diagnosis and Assessment of Therapeutic Response. Bick, Rodger L. // Clinical & Applied Thrombosis/Hemostasis;Winter1995, Vol. 1 Issue 1, p3 

    Current concepts of the etiology, pathophysiology, clinical and laboratory diagnosis, and treatment of fulminant and low-grade DIC have been presented. Considerable attention has been devoted interrelationships within the hemostasis system. Only by clearly understanding these pathophysiological...

  • Clinical: Haematology - Disseminated intravascular coagulation. Toh, Cheng-Hock; Thachil, Jecko // GP: General Practitioner;5/20/2011, p44 

    The article offers information on disseminated intravascular coagulation (DIC). DIC occurs when the human body loses its capacity to coagulate on being injured. Coagulation is an important part of hemostasis, that controls blood loss by forming clots on the wounds and injuries. DIC is caused by...

  • Schlaganfall bei Tumorpatienten. Grisold, W.; F´┐Żdinger, M.; Oberndorfer, S. // Nervenarzt;Apr2010, Vol. 81 Issue 4, p418 

    The coincidence of stroke and cancer is frequently encountered. From recent epidemiological data, the stroke risk in cancer patients seems to be equally distributed as compared to the non-cancer population. However, there are several clinical conditions in cancer patients which increase the risk...

  • Plasma Levels of Heparin Cofactor II (HCII) and Thrombin-HCII Complex in Patients with Disseminated Intravascular Coagulation. Noda, Ayako; Wada, Hideo; Kusiya, Fumihiko; Sakakura, Miho; Onishi, Katsuya; Nakatani, Kaname; Gabazza, Esteban C.; Asahara, Naomi; Tsukada, Minoru; Nobori, Tsutomu; Shiku, Hiroshi // Clinical & Applied Thrombosis/Hemostasis;Jul2002, Vol. 8 Issue 3, p265 

    Plasma levels of heparin cofactor II (HCII), thromhin-HCII complex (THC), antithrombin (AT), and thrombin-AT complex (TAT) were evaluated in patients with disseminated intravascular coagulation (DIC) associated with several underlying diseases. Plasma levels of AT were significantly reduced in...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics