Hyaluronic Acid-Carboxycellulose Membrane (Seprafilm) Reduces Early Postoperative Small Bowel Obstruction in Gastrointestinal Surgery

Mohri, Yasuhiko; Uchida, Keiichi; Araki, Toshimitu; Inoue, Yasuhiro; Tonouchi, Hitoshi; Miki, Chikao; Kusunoki, Masato
October 2005
American Surgeon;Oct2005, Vol. 71 Issue 10, p861
Academic Journal
This study aimed lo evaluate the efficacy of sodium hyaluronate and carboxymethylcellulose membrane (Seprafilm) on early postoperative small bowel obstruction (EPSBO). It also examined whether using Seprafilm affected surgical site infection rates in gastrointestinal surgery. One hundred eighty-four patients who had Seprafilm placed during gastrointestinal surgery between October 2000 and December 2003 were included in the study (Seprafilm group) and were compared with a matched cohort (control group) of patients operated on without Seprafilm. All patients were retrospectively assessed for EPSBO and surgical site infections. The incidence of EPSBO was significantly lower (P < 0.05) in the Seprafilm group (12/184) than in the control group (26/183). The incidence of surgical site infection between the Seprafilm (15.2%) and control (13.7%) groups was not statistically significant. The placement of Seprafilm helped to prevent EPSBO and had no significant adverse affect on surgical site infections.


Related Articles

  • SOME NEWER OBSERVATIONS IN SMALL BOWEL OBSTRUCTION. Ficarra, Bernard J. // American Journal of Gastroenterology;Nov1957, Vol. 28 Issue 5, p560 

    Presents current clinical and experimental observations on small bowel obstruction as of November 1957. Paths of least resistance taken by the small bowel when an obstruction is encountered; Lethal nature of obstructed bowel contents; Postulation of an axiom concerning the distention and...

  • A Comparative Analysis between Laparoscopic and Open Adhesiolysis at a Tertiary Care Center. DAVIES, STEPHEN W.; GILLEN, JAKE R.; GUIDRY, CHRISTOPHER A.; NEWHOOK, TIMOTHY E.; POPE, NICOLAS H.; HRANJEC, TJASA; SAWYER, ROBERT G.; HALLOWELL, PETER T. // American Surgeon;Mar2014, Vol. 80 Issue 3, p261 

    Laparotomy has been the favored approach regarding surgical management of small bowel obstruction (SBO); however, laparoscopy may offer improved outcomes. Patients undergoing laparoscopic lysis of adhesions (LOA) at our institution for SBO will have lower postoperative morbidity and 30-day...

  • Early outcomes of surgery for small bowel obstruction: analysis of risk factors. Oswens Siu Hung Lo; Wai Lun Law; Hok Kwok Choi; Yee Man Lee; Judy Wai Chu Ho; Chi Leung Seto // Langenbeck's Archives of Surgery;Apr2007, Vol. 392 Issue 2, p173 

    The study aimed to review the etiologies of patients who underwent surgery for small bowel obstruction (SBO) and to evaluate the risk factors affecting the early postoperative outcomes. A case series of 430 patients (252 men) with a mean age of 64.5 years, who underwent 437 operations for SBO,...

  • Volvulus of the Small Bowel in Adults. RUIZ-TOVAR, JAIME; MORALES, VICENTE; SANJUANBENITO, ALFONSO; LOBO, EDUARDO; MARTINEZ-MOLINA, ENRIQUE // American Surgeon;Dec2009, Vol. 75 Issue 12, p1179 

    The volvulus of the small bowel is a surgical emergency, causing small bowel obstruction. We performed a retrospective study of all the patients diagnosed and treated with small bowel volvulus between 1977 and 2007 at our institution. One hundred twenty-nine patients were analyzed. Thirty-nine...

  • Small bowel obstruction secondary to intragastric erosion and migration of a gastric band. Egbeare, D. M.; Myers, A. F.; Lawrence, R. J.; Lawrance, R J // Journal of Gastrointestinal Surgery;May2008, Vol. 12 Issue 5, p983 

    We describe what we believe to be the first reported case of intragastric erosion and migration to the jejenum of a laparoscopically inserted gastric band, 3 months after the original bariatric surgery was performed. This had caused ulceration and necrosis of the small bowel as the tension in...

  • Conservative Management of Adhesive Small Bowel Obstructions in Patients Previously Operated on for Primary Colorectal Cancer. Woon Kyung Jeong; Seok-Byung Lim; Hyo Seong Choi; Seung-Yong Jeong // Journal of Gastrointestinal Surgery;May2008, Vol. 12 Issue 5, p926 

    This study aimed to determine the incidence of adhesive small bowel obstruction (SBO) after primary colorectal cancer surgery and the outcomes of conservative management using gastrointestinal tubes in such cases. Between October 2000 and December 2005, 2,586 primary colorectal cancer patients...

  • Adhesions are common and costly after open pouch surgery. Sileri, Pierpaolo; Sthory, Roberto; McVeigh, Enda; Child, Tim; Cunningham, Chris; Mortensen, Neil J.; Lindsey, Ian // Journal of Gastrointestinal Surgery;Jul2008, Vol. 12 Issue 7, p1239 

    Purpose: Open ileal pouch surgery leads to high rates of adhesive small-bowel obstruction (SBO). A laparoscopic approach may reduce these complications. We aimed to review the incidence of adhesive SBO-related complications after open pouch surgery and to model the potential...

  • Partial small bowel obstruction: clinical issues and recent technical advances. Kendrick, Michael L. // Abdominal Imaging;May/Jun2009, Vol. 34 Issue 3, p329 

    Mechanical small bowel obstruction (SBO) remains a common clinical problem despite ever-increasing medical and surgical advances. The predominant etiology continues to be postoperative adhesions, accounting for approximately two-thirds of all obstructive events. As opposed to high-grade or...

  • Small Bowel Obstructions in a Virgin Abdomen: Is an Operation Mandatory? TAVANGARI, FAREES RICKY; BATECH, MICHAEL; COLLINS, J. CRAIG; TEJIRIAN, TALAR // American Surgeon;Oct2016, Vol. 82 Issue 10, p1038 

    Though conventionally not considered standard of care, nonoperative management of patients with small bowel obstruction (SBO) without previous abdominal operations, so called "virgin abdomens," (VA) is presently being practiced. We aimed to determine outcomes of patients with VA undergoing...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics