TITLE

Intravenous Iron Sucrose versus Oral Iron Supplementation for the Treatment of Iron Deficiency Anemia in Patients with Inflammatory Bowel Disease–A Randomized, Controlled, Open-Label, Multicenter Study

AUTHOR(S)
Schröder, Oliver; Mickisch, Oliver; Seidler, Ursula; de Weerth, Andreas; Dignass, Axel U.; Herfarth, Hans; Reinshagen, Max; Schreiber, Stefan; Junge, Ulrich; Schrott, Marc; Stein, Jürgen
PUB. DATE
November 2005
SOURCE
American Journal of Gastroenterology;Nov2005, Vol. 100 Issue 11, p2503
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
OBJECTIVES: Anemia is a frequent complication in patients with inflammatory bowel disease (IBD). The optimal route for iron supplementation to replenish iron stores has not been determined so far. We therefore evaluated the efficacy and safety of intravenous iron sucrose as compared with oral iron sulfate for the treatment of iron deficiency anemia (IDA) in patients with IBD. METHODS: A randomized, prospective, open-label, multicenter study was performed in 46 patients with anemia and transferrin saturation ≤20% and/or serum ferritin concentrations ≤20 μg/L. The intravenous group received a single dose of iron sucrose of 7 mg iron/kg body weight, followed by five 200 mg infusions for the following 5 wks. The oral group received iron sulfate 100–200 mg per day for 6 wks. RESULTS: While a comparable increase in hemoglobin was observed for both administration routes (median increase 0.25 g/L in the intravenous group vs 0.21 g/L in the oral group), only iron sucrose led to a rise in serum ferritin concentrations. Intractable gastrointestinal adverse events caused permanent study drug discontinuation in five patients (20.8%) receiving iron sulfate, whereas only one patient (4.5%) had to be withdrawn because of side effects due to iron sucrose. CONCLUSIONS: Although being equal in short-term efficacy and overall tolerability our results suggest a better gastrointestinal tolerability for iron sucrose. Larger trials are mandatory to prove a possible advantage of iron sucrose in short- and long-term efficacy as well as in tolerability over iron sulfate in the management of IDA in IBD.
ACCESSION #
18613684

 

Related Articles

  • Anemia.  // American Medical Association Family Medical Guide;2004, p610 

    The article focuses on the various types of anemia, a deficiency of red blood cells in the human body. Iron deficiency anemia develops if the body loses more iron than it absorbs and if the bone marrow produces fewer and smaller red blood cells. If the body is deprived of an adequate supply of...

  • Iron Deficiency Anemia.  // Diseases & Disorders: A Nursing Therapeutics Manual, 2nd edition;2002, p562 

    Presents information about the iron deficiency anemia disorder. Complications from iron deficiency anemia; Causes of the disease; Nursing assessment and diagnosis; Treatment.

  • Managing iron deficiency anaemia in the practice. Knott, Laurence // GP: General Practitioner;2/2/2007, p32 

    The article focuses on the treatment of iron deficiency anaemia. Iron deficiency anaemia occurs in between 2 and 5 percent of adult males and postmenopausal women and in between 5 and 12 percent of pre-menopausal women in the developed world. Iron balance is controlled mainly by absorption in...

  • Age-related changes in hookworm infection, anaemia and iron deficiency in an area of high Necator americanus hookworm transmission in south-eastern Brazil. Brooker, Simon; Jardim-Botelho, Anne; Quinnell, Rupert J.; Geiger, Stefan M.; Caldas, Iramaya R.; Fleming, Fiona; Hotez, Peter J.; Correa-Oliveira, Rodrigo; Rodrigues, Laura C.; Bethony, Jeffrey M. // Transactions of the Royal Society of Tropical Medicine & Hygiene;Feb2007, Vol. 101 Issue 2, p146 

    Summary: Surprisingly few detailed age-stratified data exist on the epidemiology of hookworm and iron status, especially in Latin America. We present data from a cross-sectional survey examining 1332 individuals aged 0–86 years from a community in south-east Brazil for hookworm, anaemia...

  • Intravenous iron sucrose -- an effective and attractive modality for perioperative anaemia management. FROESSLER, B.; APENDORF, D. // Anaesthesia & Intensive Care;Sep2010, Vol. 38 Issue 5, p960 

    The article discusses the effectiveness of intravenous iron sucrose for treating perioperative anaemia. Studies showed that iron deficiency anaemia is commonly experienced by patients presenting for surgery. Among the causes of iron deficiency anaemia include poor nutrition, age and...

  • Diagnostic Yield of Capsule Endoscopy in a Tertiary Hospital in Patients with Obscure Gastrointestinal Bleeding. van Turenhout, Sietze T.; Jacobs, Maarten A. J. M.; van Weyenberg, Stijn J.; Herdes, Erik; Stam, Fred; Mulder, Chris J. J.; Bouma, Gerd // Journal of Gastrointestinal & Liver Diseases;Jun2010, Vol. 19 Issue 2, p141 

    Background & Aims. Capsule endoscopy is applicable to several clinical conditions, but obscure gastrointestinal bleeding remains the main indication. This study aims at determining the diagnostic yield of capsule endoscopy for obscure gastrointestinal bleeding using a structured terminology in a...

  • Iron Medication—Associated Gastric Mucosal Injury. Hongxiu Ji; Yardley, John H. // Archives of Pathology & Laboratory Medicine;Jul2004, Vol. 128 Issue 7, p821 

    This article discusses a case of iron medication, associated gastric mucosal injury. An endoscopic antral biopsy specimen was taken from a 48-year-old, white woman with iron deficiency anemia who was currently taking ferrous sulfate, 250-mg tablets, twice a day. Oral iron medication has been...

  • Diminished Platelet Aggregation in Patients with Iron Deficiency Anemia. Çaliskan, Ümran; Öner, Ahmet Faik; Kabakus, Nimet; Koç, Hasan // Clinical & Applied Thrombosis/Hemostasis;Jul1999, Vol. 5 Issue 3, p161 

    To evaluate platelet function in iron deficiency anemia, using impedance (in whole blood) and optic (in platelet-rich plasma methods, platelet aggregation analyses were performed in 42 children with iron deficiency anemia at the time of diagnosis and after iron therapy. Collagen-induced platelet...

  • IRON DEFICIENCY: ANAEMIA.  // Pulse;4/6/2006, Vol. 66 Issue 14, p42 

    The article presents answers to queries related to iron deficiency anemia. Medical experts discussed the hemoglobin levels that are considered to be abnormal for children and adults. The factors affecting iron absorption are also discussed and the effects of iron deficiency on infants and...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics