TITLE

Palliation of Nonresectable Bile Duct Cancer: Improved Survival After Photodynamic Therapy

AUTHOR(S)
Zoepf, Thomas; Jakobs, Ralf; Arnold, Joachim C.; Apel, Darius; Riemann, Jürgen F.
PUB. DATE
November 2005
SOURCE
American Journal of Gastroenterology;Nov2005, Vol. 100 Issue 11, p2426
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
OBJECTIVES: Preliminary uncontrolled studies of photodynamic therapy (PDT) of bile duct cancer (BDC) have shown astonishingly good results in the reduction of cholestasis, improvement of life quality, and potential improvement of survival time. Therefore, we investigated the influence of PDT on survival time in advanced BDC in a randomized controlled study. METHODS: Thirty-two patients with nonresectable BDC were randomized. In the PDT group 48 h after intravenous application of 2 mg/kg body weight of Photosan-3®, light activation was performed. In the control group, patients were treated with endoprostheses but no PDT. RESULTS: PDT group and the control group were comparable due to age, gender, performance status, bilirubin level, and BDC stage (Bismuth classification). The median survival time after randomization was 7 months for the control group and 21 months for the PDT group ( p= 0.0109). In half of the initially percutaneously treated patients, we could change from percutaneous to transpapillary drainage after PDT. Four patients showed infectious complications after PDT versus one patient in the control group. DISCUSSION: PDT is minimally invasive but shows a considerable postinterventional cholangitis rate. PDT has the potential to result in a changeover of current palliative treatment of BDC.
ACCESSION #
18613656

 

Related Articles

  • Chemotherapy may worsen QOL near death.  // PharmacoEconomics & Outcomes News;Aug2015, Vol. 734 Issue 1, p5 

    The article reports on the findings of a study published in "JAMA Oncology" journal which reveal that palliative chemotherapy in patients with end-stage cancer may worsen quality of life (QOL) near death.

  • Photodynamic Therapy for Palliation of Nonresectable Bile Duct Cancer--Preliminary Results With a New Diode Laser System. Zoepf, Thomas; Jakobs, Ralf; Arnold, Joachim C.; Apel, Darius; Rosenbaum, Anika; Riemann, Jürgen F. // American Journal of Gastroenterology;Jul2001, Vol. 96 Issue 7, p2093 

    OBJECTIVES: Preliminary results of photodynamic therapy (PDT) of bile duct cancer have shown astonishingly good results in the reduction of cholestasis, improvement of quality of life, and even prolongation of the survival time. Unfortunately, the existing dye laser systems are large and costly,...

  • The applicability of quality-of-life assessment in palliative care: comparing two quality-of-life measures. Pratheepawanit, N.; Salek, M.; Finlay, I. // Palliative Medicine;1999, Vol. 13 Issue 4, p325 

    Two self-administered quality-of-life measures, the McGill Quality of Life Questionnaire (MQOL) and the Patient Evaluated Problem Scores (PEPS) were compared in patients receiving palliative care. The MQOL is a multidimensional questionnaire consisting of 16 items in five quality-of-life (QOL)...

  • Palliative care in cancer: An overview. Figueiredo de Carvalho, Sionara Melo; Rolim Neto, Modesto Leite; Chaves de Carvalho, Idelfonso Oliveira; Santiago Freitas, Lara Ribeiro; Leite, Ingrid Ramalho; Celestino Junior, Francisco Telesforo; Brasil, Aline Quental; Leandro, Jamille Ferreira // HealthMed;2013, Vol. 7 Issue 3, p859 

    Introduction: In cancer treatment, focus eventually has to shift from curing to palliating, an approach called cancer palliative care. This literature review aimed at analyzing the existing studies on cancer palliative care on a broad perspective. Methods: A search was conducted via electronic...

  • The meaning of hope from the perspective of Chinese advanced cancer patients in Hong Kong. Mok, Esther; Wai Man Lam; Lai Ngor Chan; Ka Po Lau; Ng, Jeffrey S. C.; Kin Sang Chan // International Journal of Palliative Nursing;Jun2010, Vol. 16 Issue 6, p298 

    Aim: This article reports a study to examine the meaning of hope from the perspective of Chinese advanced cancer patients in Hong Kong. Methods: Semi-structured interviews were conducted with a convenience sample of advanced cancer patients recruited from the palliative care unit of a local...

  • Feasibility of quality of life assessment in patients with upper gastrointestinal tract cancer. Blazeby, J M; Nicklin, J; Brookes, S T; Winstone, K; Alderson, D // British Journal of Cancer;8/4/2003, Vol. 89 Issue 3, p497 

    Quality of life (QOL) is an important outcome after treatment for upper gastrointestinal tract cancer but few studies report good accrual and subsequent attrition is usually high. This study investigated the feasibility of a nurse-led service to obtain longitudinal QOL assessments and explored...

  • Palliative hepatic intraarterial chemotherapy (HIC) using a novel combination of gemcitabine and mitomycin C: results in hepatic metastases. Vogl, Thomas J.; Zangos, Stephan; Eichler, Katrin; Selby, J. Bayne; Bauer, Ralf W. // European Radiology;Mar2008, Vol. 18 Issue 3, p468 

    To evaluate repeated hepatic intraarterial chemotherapy (HIC) as a palliative treatment option for unresectable cholangiocarcinoma and liver metastases of various origins that were progressive under systemic chemotherapy. Between 2002 and 2006, 55 patients were treated in 4-week intervals (mean...

  • Colorectal cancer in the elderly—surgical treatment and long-term survival. Schiffmann, L.; Özcan, S.; Schwarz, F.; Lange, J.; Prall, F.; Klar, E. // International Journal of Colorectal Disease;Jun2008, Vol. 23 Issue 6, p601 

    The prognosis of radical treatment for colorectal cancer in elderly patients has been subject of controversies. The aim of this study was to compare patients at the age of 75 years or older with a group of younger patients, focused on the clinicopathologic characteristics and the results of...

  • Photodynamic Therapy for Unresectable Cholangiocarcinoma. Tomizawa, Yutaka; Tian, Jianmin // Digestive Diseases & Sciences;Feb2012, Vol. 57 Issue 2, p274 

    Cholangiocarcinoma (CC) is a rare primary malignancy of the biliary tract with a dismal prognosis. Curative resection can only be applied to a small proportion of early diagnosed patients. Palliative biliary drainage by either percutaneous or endoscopic insertion of endoprostheses improves...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics