TITLE

Synthesis and Anti-Breast Cancer Activity of Tetrasubstituted Pyrrole Derivatives

AUTHOR(S)
Padron, Jose M.; Tejedor, David; Santos-Exposito, Alicia; Garcia-Tellado, Fernando; Villar, Jesús; Martin, Víctor S.
PUB. DATE
November 2005
SOURCE
Letters in Drug Design & Discovery;Nov2005, Vol. 2 Issue 7, p529
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
A series of tetrasubstituted pyrrole derivatives, structurally related to tyrosine kinase inhibitors, has been synthesized one-pot by irradiation of a silica gel absorbed mixture of a conjugated alkynoate and a primary amine. The compounds were evaluated for their anticancer activities using the human breast cancer cell lines, T-47D and MCF7.
ACCESSION #
18573478

 

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