TITLE

Synthesis and Anti-Mycobacterial Activity of N'-[(E)-(Disubstituted- Phenyl)Methylidene]Isonicotino-Hydrazide Derivatives

AUTHOR(S)
Junior, Ivan N.; Lourençco, Maria C. S.; Henriques, Maria das Graças M. O.; Ferreira, Barbara; Vasconcelos, Thatyana R. A.; Peralta, Mônica A.; de Oliveira, Pedro S. M.; Wardell, Solange M. S. V.; de Souza, Marcus V. N.
PUB. DATE
November 2005
SOURCE
Letters in Drug Design & Discovery;Nov2005, Vol. 2 Issue 7, p563
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
A series of eight N'-[(E)-(disubstituted-phenyl)methylidene]isonicotino-hydrazide derivatives were synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis, and the activity expressed as the minimum inhibitory concentration (MIC) in mg/mL. Four compounds 2b-d and 2f exhibited a significant activity (0.6 mg/mL), when compared with first line drugs such as isoniazid (INH) and rifampin (RIP) and could be a good starting point to develop new lead compounds in the fight against multidrug resistant tuberculosis.
ACCESSION #
18573472

 

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