Stromal Cell--Derived Factor--1 Genotype, Coreceptor Tropism, and HIV Type 1 Disease Progression

Daar, Eric S.; Lynn, Henry S.; Donfield, Sharyne M.; Lail, Alice; O'Brien, Stephen J.; Wei Huang; Winkler, Cheryl A.
November 2005
Journal of Infectious Diseases;11/1/2005, Vol. 192 Issue 9, p1597
Academic Journal
This study used a well characterized cohort of human immunodeficiency virus type 1 (HIV-1)-infected hemophiliacs to define the relationship between the SDF1-3'A allele, the plasma HIV-1 coreceptor tropism, and the natural history of HIV-1 disease. Subjects heterozygous or homozygous for the SDF1-3'A allele experienced higher rates of decline in CD4+ T cell counts over time than did those without the allele (P = .009). Moreover, they had an increased risk of progression to acquired immunodeficiency syndrome and death, a relationship that persisted even when baseline plasma HIV-1 RNA levels and CD4+ T cell counts or CCR5Δ32 and CCR2- 64I genotype were controlled for. This relationship was even stronger in a subgroup of subjects for whom tropism data were available. Subjects with the SDF1-3'A allele were also more likely to have detectable X4- tropic viruses (P = .012), and, when tropism was included in the survival analyses, the effect of the SDF1-3'A allele on disease progression was no longer significant. Therefore, the increased frequency of X4-tropic viruses in subjects carrying the SDF1-3'A allele may explain the observed adverse effect that this allele has on the natural history of HIV-1 disease.


Related Articles

  • HIV-1 Envelope Protein gp120 Is Present at High Concentrations in Secondary Lymphoid Organs of Individuals with Chronic HIV-1 Infection. Santosuosso, Michael; Righi, Elda; Lindstrom, Victoria; Leblanc, Pierre R.; Poznansky, Mark C. // Journal of Infectious Diseases;10/1/2009, Vol. 200 Issue 7, p1050 

    The envelope protein of human immunodeficiency virus type 1 (HIV-1)-glycoprotein 120 (gp120)-has been demonstrated to dysregulate T cell function in vitro. We obtained autopsy tissues from individuals with chronic HIV-1 infection to determine whether there was enough gp120 in lymphoid tissues...

  • Acute HIV-1 Infection. Cohen, Myron S.; Shaw, George M.; McMichael, Andrew J.; Haynes, Barton F. // New England Journal of Medicine;5/19/2011, Vol. 364 Issue 20, p1943 

    The article focuses on human immunodeficiency virus type 1 (HIV-1) transmission and acute HIV-1 infection. It is said that more than 80 percent of adults infected with HIV-1 became infected through the exposure of mucosal surfaces to the virus, while most of the remaining 20 percent were...

  • Default in plasma and intestinal IgA responses during acute infection by simian immunodeficiency virus. Chaoul, Nada; Burelout, Chantal; Peruchon, Sandrine; van Buu, Beatrice Nguyen; Laurent, Pascale; Proust, Alexis; Raphael, Martine; Garraud, Olivier; Le Grand, Roger; Prevot, Sophie; Richard, Yolande // Retrovirology;2012, Vol. 9 Issue 1, p43 

    Background: Conflicting results regarding changes in mucosal IgA production or in the proportions of IgA plasma cells in the small and large intestines during HIV-infection have been previously reported. Except in individuals repeatedly exposed to HIV-1 but yet remaining uninfected, HIV-specific...

  • Why Does HIV Infection Not Lead to Disseminated Strongyloidiasis? Viney, Mark E.; Brown, Michael; Omoding, Nicholas E.; Bailey, J. Wendi; Gardner, Michael P.; Roberts, Emily; Morgan, Dilys; Elliott, Alison M.; Whitworth, James A. G. // Journal of Infectious Diseases;12/15/2004, Vol. 190 Issue 12, p2175 

    We investigated the hypothesis that host immunosuppression due to advancing human immunodeficiency virus (H IV) disease favors the direct development of infective larvae of Strongyloides stercoralis, which may facilitate hyperinfection and, hence, disseminated strongyloidiasis. To do this, we...

  • The global distribution of CCR5 delta 32 polymorphism: role in HIV-1 protection. Gupta, Anuroopa; Padh, Harish // BMC Infectious Diseases;2012 Supplement, Vol. 12 Issue Supplment 1, p1 

    The article discusses a study on the role of the global distribution of CCR5delta 32 polymorphism in the protection against human immunodeficiency virus type 1 (HIV-1) infection. The study examines the CCR5-32 base pair deletion by conventional polymerase chain reaction (PCR) of 257 healthy...

  • Changing Patterns in HIV Reverse Transcriptase Resistance Mutations after Availability of Tenofovir. de Mendoza, Carmen; Jiménez-Nacher, Inmaculada; Garrido, Carolina; Barreiro, Pablo; Poveda, Eva; Corral, Angélica; Zahonero, Natalia; González-Lahoz, Juan; Soriano, Vincent // Clinical Infectious Diseases;6/1/2008, Vol. 46 Issue 11, p1782 

    Assessment of 1177 human immunodeficiency virus (HIV) resistance genotypes at an HIV/AIDS clinic showed a decrease in the incidence of the K65R mutation, from 15.2% of isolates during the period 2002-2004 to 2.7% of isolates during the period 2005-2006 (P <.001), despite elevated and stable...

  • Detrimental Effects of Mannose-Binding Lectin (MBL2) Promoter Genotype XA/XA on HIV-1 Vertical Transmission and AIDS Progression. Mangano, A.; Rocco, C.; Marino, S. M.; Mecikovsky, D.; Genre, F.; Aulicino, P.; Bologna, R.; Sen, L. // Journal of Infectious Diseases;9/1/2008, Vol. 198 Issue 5, p694 

    Background. The literature on the involvement of mannose-binding lectin (MBL) in human immunodeficiency virus (HIV) transmission and acquired immunodeficiency syndrome (AIDS) is conflicting. Polymorphisms in the MBL2 gene reduce the level of protein and alter its structure. Thus, we investigated...

  • The dynamics of CD4+ T-cell depletion in HIV disease. McCune, Joseph M. // Nature;4/19/2001, Vol. 410 Issue 6831, p974 

    The size and composition of the CD4+ T-cell population is regulated by balanced proliferation of progenitor cells and death of mature progeny. After infection with the human immunodeficiency virus, this homeostasis is often disturbed and CD4+ T cells are instead depleted. Such depletion cannot...

  • HIV: Cross-talk and viral reservoirs. Pomerantz, Roger J. // Nature;7/10/2003, Vol. 424 Issue 6945, p136 

    Human immunodeficiency virus type 1 (HIV-1) infects many cells in the human host, but there are two major targets macrophages and CD4 T cells. Over the years, the list of complicated ways in which the virus is known to behave has grown. Researchers show how, through stimulating interaction...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics