Clopidogrel Hypersensitivity Syndrome With Rash, Fever, and Neutropenia

Doogue, Matthew P.; Begg, Evan J.; Bridgman, Paul
October 2005
Mayo Clinic Proceedings;Oct2005, Vol. 80 Issue 10, p1368
Academic Journal
We report a case of a severe hypersensitivity syndrome reaction to clopidogrel that resolved with dechallenge and recurred on rechallenge. The reaction included neutropenia, rash, fever, tachycardla, nausea, and vomiting. This presentation is very similar to the frequently reported hypersensitivity syndrome reactions to the structurally similar drug ticlopidine and is very similar to a case involving clopidogrel reported previously in this journal. We could find no other reports of similar cases related to clopidogrel.


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