TITLE

Cardiovascular Risk Factor Profiles and Kidney Function Stage in the US General Population: The NHANES III Study

AUTHOR(S)
Foley, Robert N.; Changchun Wang; Collins, Allan J.
PUB. DATE
October 2005
SOURCE
Mayo Clinic Proceedings;Oct2005, Vol. 80 Issue 10, p1270
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
OBJECTIVE: To determine the prevalence of cardiovascular risk factors in the general population based on kidney function. SUBJECTS AND METHODS: We retrospectively analyzed data from the Third National Health and Nutrition Examination Survey of noninstitutionalized US adults, which was conducted from 1988 to 1994. Data were gathered on 9 cardiovascular risk factors (smoking; obesity; hypertension; high total cholesterol, C-reactive protein, glycosylated hemoglobin, and homocysteine levels; low hemoglobin level; and high urinary albumin-to-creatinine ratio) and estimated glomerular filtration rate (GFR). RESULTS: For the 15,837 subjects, the estimated GFR was at least 90 mL/min per 1.73 m² (normal) in 65.4%, 60 to 89.9 mL/min per 1.73 m² (stage 2 kidney function) in 27.9%, 30 to 59.9 mL/min per 1.73 m² (stage 3 kidney function) in 6.2%, and less than 30 mL/min per 1.73 m² (stages 4 and 5 kidney function) in 0.5%. The number of cardiovascular risk factors increased with stage of kidney dysfunction. Of subjects with a normal GFR, 30.4% had no risk factors, 34.9% had 1 risk factor, and 34.7% had 2 or more risk factors. Of subjects with stage 2 kidney function, 24.8% had no risk factors, 30.3% had 1 risk factor, and 44.9% had 2 or more risk factors. Of subjects with stage 3 kidney function, 1.4% had no risk factors, 14.9% had 1 risk factor, and 83.6% had 2 or more risk factors. All subjects with stages 4 and 5 kidney function had 2 or more risk factors. After covariate adjustment, odds ratios for having an estimated GFR lower than 60 mL/min per 1.73 m² were 1, 3.7 (95% confidence interval, 1.2–11.3), and 10.4 (95% confidence interval, 3.9–27.8) times greater in subjects with 0, 1, and 2 or more cardiovascular risk factors, respectively (P≤.001). CONCLUSION: Persons with chronic kidney disease are much more likely to need multiple cardiovascular risk factor interventions than those without chronic kidney disease.
ACCESSION #
18540651

 

Related Articles

  • Mineralocorticoid hypertension. Gupta, Vishal // Indian Journal of Endocrinology & Metabolism;Oct2011 Supplement, pS298 

    Hypertension affects about 10 -- 25% of the population and is an important risk factor for cardiovascular and renal disease. The renin-angiotensin system is frequently implicated in the pathophysiology of hypertension, be it primary or secondary. The prevalence of primary aldosteronism increases...

  • Preclinical Kidney Disease in Elderly People.  // Annals of Internal Medicine;8/15/2006, Vol. 145 Issue 4, pI22 

    The article cites a study which founds out that patient with preclinical kidney disease are prone to cardiovascular disease and death compared to patients with chronic kidney disease. The objective of the study was to compare the risk of cardiovascular diseases in older man with normal kidney...

  • Mechanisms of arterial calcifications and consequences for cardiovascular function. London, Gérard M // Kidney International Supplements;Dec2013, Vol. 3 Issue 5, p442 

    Cardiovascular complications are the leading cause of mortality in chronic (CKD) and end-stage renal disease (ESRD). The risk of developing cardiovascular complications is associated with changes in the structure and function of the arterial system, which are in many aspects similar to those...

  • Examining the evidence on vitamin D, calcium, and CVD risk. WANG, LU; SESSO, HOWARD D.; MANSON, JOANN E. // Contemporary OB/GYN;Feb2012, Vol. 57 Issue 2, p34 

    The article discusses evidence from several studies which show the effect dietary and supplemental vitamin D and calcium on cardiovascular disease (CVD) risk in adults. Observational studies show that 25-hydroxyvitamin D [25(OH)D] levels and CVD risk are inversely related and show lack of...

  • Microalbuminuria Found to Increase CKD Risk.  // Renal & Urology News;Jun2010, Vol. 9 Issue 6, p33 

    The article reports on the findings of a study regarding the risk of cardiovascular and chronic kidney diseases in hypertensive patients with microalbuminuria in Italy.

  • Na = Not Appropriate: Salt, CVD, and CVA. Greenfield, Russell H. // Alternative Medicine Alert;Feb2010, Vol. 13 Issue 2, p18 

    THE AUTHORS OF THIS SYSTEMATIC REVIEW AND META-analysis investigated the documented relationship between salt intake and CVA or total CVD outcome in adults. Culling data from Medline, Embase, AMED, CINAHL, Psychinfo, and the Cochrane Library, multiple analyses were performed on the prospective...

  • Toothbrushing, inflammation, and risk of cardiovascular disease: Results from Scottish Health Survey. Williams, David S. // Journal of Insurance Medicine;2011, Vol. 42 Issue 2-4, p101 

    A review of the article "Toothbrushing, inflammation, and Risk of Cardiovascular Disease: Results From Scottish Health Survey," by C. De Oliveira et al, published in a 2010 issue of the "British Medical Journal" is presented.

  • Cardiovascular complications in pediatric end-stage renal disease. Parekh, Rulan S.; Gidding, Samuel S. // Pediatric Nephrology;Feb2005, Vol. 20 Issue 2, p125 

    Mortality from end-stage renal disease (ESRD) is often due to cardiac causes. Although cardiovascular complications of ESRD have long been recognized, only recently has the presence of traditional cardiovascular risk factors been associated with late cardiovascular complications. This review...

  • Progenitor cells and vascular function are impaired in patients with chronic kidney disease. Jie, Kim E.; Zaikova, Masha A.; Bergevoet, Marloes W.T.; Westerweel, Peter E.; Rastmanesh, Mehdi; Blankestijn, Peter J.; Boer, Walther H.; Braam, Branko; Verhaar, Marianne C. // Nephrology Dialysis Transplantation;Jun2010, Vol. 25 Issue 6, p1875 

    Background. Endothelial dysfunction contributes to accelerated atherosclerosis in chronic kidney disease (CKD). Bone marrow-derived endothelial progenitor cells (EPC) constitute an endogenous vascular repair system protecting against atherosclerosis. Smooth muscle progenitor cells (SPC) may...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics