Angulo, Frederick J.
October 2005
Clinical Infectious Diseases;10/15/2005, Vol. 41 Issue 8, p1167
Academic Journal
Botulism is a rare disease with 4 naturally occurring syndromes: foodborne botulism is caused by ingestion of foods contaminated with botulinum toxin, wound botulism is caused by Clostridium botulinum colonization of a wound and in situ toxin production, infant botulism is caused by intestinal colonization and toxin production, and adult intestinal toxemia botulism is an even rarer form of intestinal colonization and toxin production in adults. Inhalational botulism could result from aerosolization of botulinum toxin, and iatrogenic botulism can result from injection of toxin. All forms of botulism produce the same distinct clinical syndrome of symmetrical cranial nerve palsies followed by descending, symmetric flaccid paralysis of voluntary muscles, which may progress to respiratory compromise and death. The mainstays of therapy are meticulous intensive care (including mechanical ventilation, when necessary) and timely treatment with antitoxin.


Related Articles

  • Deadly Botulism. Simpson, Lance L. // Natural History;Jan80, Vol. 89 Issue 1, p12 

    Discusses various aspects of botulism. Food poisoning due to the bacterium Clostridium botulinum; Synthesis of botulinum toxin; Mechanism of food poisoning; Outbreak of botulism; Interaction between botulism toxin and nerve endings.

  • Botulinum Neurotoxins: More and More Diverse and Fascinating Toxic Proteins. Popoff, Michel R. // Journal of Infectious Diseases;Jan2014, Vol. 209 Issue 2, p168 

    The author reflects on the clinical symptoms of botulism, a disease resulting from food poisoning or intestinal colonization, the spread of the disease, and different forms of the diseases with reference to various studies relating to the subject. Topics discussed include botulinum neurotoxin,...

  • botulism.  // Taber's Cyclopedic Medical Dictionary (2009);2009, Issue 21, p301 

    An encyclopedia entry for "botulism" is presented. It refers to a paralytic and occasionally fatal illness due to exposure to toxins released from Clostrodium botulinum, an anaerobic, gram-positive bacillus. The disease usually occurs after eating food contaminated by the toxin, after...

  • Botulism.  // A-Z of Food Safety;2007, p36 

    An encyclopedia entry for "Botulism" is presented. It refers to a disease caused by toxins of Clostridium botulinum, which often attacks the nervous system. The incubation period of the disease ranges from 18 to 36 hours. Symptoms include diarrhoea, headache, tiredness, double vision, loss of...

  • Botulism From Drinking Prison-Made Illicit Alcohol -- Utah 2011. Thurston, Diana; Risk, Ilene; Hill, Mary B.; Vitek, Dagmar; Bogdanow, Linda; Robertson, Jennifer; Price, Andrea; Smith, Lori; Rao, Agam; Dykes, Janet; Luquez, Carolina; Walters, Maroya // MMWR: Morbidity & Mortality Weekly Report;10/5/2012, Vol. 61 Issue 39, p782 

    The article discusses the case of botulism outbreak at the Utah State Prison in Salt Lake County during October 2-4, 2011 caused by pruno, an illicit alcoholic brew. Foodborne botulism is caused by eating food contaminated by Clostridium botulinum toxin. It cites the principal ingredients in...

  • Botulism. Wenham, Tim; Cohen, Andrew // Continuing Education in Anaesthesia, Critical Care & Pain;Feb2008, Vol. 8 Issue 1, p21 

    The article offers information on botulism, a disease that can be caused by accidental or deliberate exposure to botulinum toxins. Food-borne botulism usually follows ingestion of home preserved meat, fish or vegetables. Wound botulism, intestinal colonization botulism, and accidental botulism...

  • CLINICAL AND PARACLINICAL ASPECTS IN A CASE OF A BOTULINUS INFECTION. Stancu, Alexandra; Dupel, Corinne Pottier; Mindruta, Ioana; Tiu, Cristina // Romanian Journal of Neurology;Jun2007, Vol. 6 Issue 2, p100 

    We depict the case of a patient who progressively develops a motor deficit and respiratory failure, which eventually proves to be botulinus intoxication, after a series of puzzling results of various investigations leading to a different diagnosis.

  • Allergan's Botox not involved in Fla. poisonings.  // Cosmetic Surgery Times;Jan/Feb2005, Vol. 8 Issue 1, p1 

    This article reports that California pharmaceutical manufacturer Allergan Inc. is taking steps to reassure doctors and patients about the safety of Botox after four people became critically ill after treatment with unapproved raw botulinum toxin. At press time, both the unlicensed South Florida...

  • Botulin Toxin: A Weapon in Terrorism. Josko, Deborah // Clinical Laboratory Science;Winter2004, Vol. 17 Issue 1, p30 

    Presents information on the botulism causative agent Clostridium (C.) botulinum. Characteristics of C. botulinum; Uses of C. botulinum as a biological weapon; Types of clinical manifestations taken by botulism; Diseases treatable by C. botulinum toxin.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics