Amniotic Fluid Cardiac Troponin T in Pathological Pregnancies with Evidence of Chronic Fetal Hypoxia

Stefanović, Vedran; Loukovaara, Mikko
October 2005
Croatian Medical Journal;2005, Vol. 46 Issue 5, p801
Academic Journal
Aim To determine if prenatally measured cardiac troponin T in the amniotic fluid (Am-TnT) could be used as a marker of fetal myocardial hypoxia and necrosis in pathological pregnancy characterized by increased concentration of amniotic fluid erythropoietin (Am-EPO) as a sign of chronic fetal hypoxia. Method We measured Am-TnT and Am-EPO in 29 pathological and 5 uncomplicated pregnancies. Samples of amniotic fluid were collected prospectively during elective amniocentesis (n=15), cesarean sections (n=17), and before elective induction of labor in two pregnancies with stillbirth. Am-TnT and Am-EPO were determined by chemiluminescent immunological method. Results Am-TnT was undetectable in normal pregnancies, but it was detectable in 9 of 29 amniotic fluid samples from pathological pregnancies, with a median value of 0.030 µg/L (range, 0.010-111.6 µg/L). Am-EPO values were above normal values (>11 U/L) in all pathological pregnancies. Am-EPO concentration showed positive correlation with the Am-TnT concentration (r=0.526, P=0.003). Median concentration of Am-EPO in 9 pregnancies with detectable Am-TnT was 198 U/L (range, 16-3,378 U/L). In 20 pathologic pregnancies with undetectable Am-TnT, the median concentration of Am-EPO was 39 U/L (range, 12-293 U/L). There was no statistically significant difference between the groups (P=0.051). Conclusion Am-TnT is measurable in some pathological pregnancies with signs of fetal chronic hypoxia andmyocardial involvement and could be potentially used as a biochemical marker of fetalmyocardial injury.


Related Articles

  • High amniotic fluid erythropoietin levels are associated with an increased frequency of fetal and neonatal morbidity in Type 1 diabetic pregnancies. Teramo, K.; Kari, M. A.; Eronen, M.; Markkanen, H.; Hiilesmaa, V. // Diabetologia;Oct2004, Vol. 47 Issue 10, p1695 

    Aims/hypothesis. In this study we investigated whether chronic fetal hypoxia, as indicated by amniotic fluid erythropoietin levels, is associated with perinatal morbidity in Type 1 diabetic pregnancies. Methods. A total of 331 women with Type 1 diabetes had at least one childbirth between 1995...

  • Inducing labour reduces the risk of caesarean delivery by 12%. Kmietowicz, Zosia // BMJ: British Medical Journal;5/3/2014, Vol. 348 Issue 7956, p1 

    The article discusses an analysis by researchers led by professor Khalid Khan, which found that the risk of caesarean delivery was 12 percent lower with labour induction than with expectant management.

  • Elective induction of labour is associated with decreased perinatal mortality and lower odds of caesarean section at 40 and 41 weeks. Caughey, Aaron B. // Evidence Based Medicine;Jun2013, Vol. 18 Issue 3, p117 

    The article discusses a study which showed the association of elective induction of labour with decreased perinatal mortality. It states that women with elective induction of labour at 37 weeks' gestation were compared to those who preceded by 38 weeks and beyond. It resulted that elective...

  • Preventive Induction of Labor: Potential Benefits if Proved Effective. Caughey, Aaron B. // Annals of Family Medicine;Jul/Aug2007, Vol. 5 Issue 4, p292 

    The author reflects on the efficacy of preventive induction of labor on the decrease of cesarean delivery rates in the U.S. He stressed that it is a form of management scheme that may appease those who wish to enhance their chances of achieving vaginal birth while offering control to the...

  • Fetal consequences of amniotic fluid meconium. Benirschke, Kurt // Contemporary OB/GYN;Jun2001, Vol. 46 Issue 6, p76 

    Presents information on a study which examined the fetal consequences of amniotic fluid meconium. Toxic effect of meconium; Mechanisms of meconium toxicity; Role of meconium in fetal hypoxia; Conclusions.

  • Impact of amniotic fluid volume on perinatal outcome.  // American Family Physician;1/1/1996, Vol. 53 Issue 1, p344 

    Discusses the article `The impact of amniotic fluid volume assessed intrapartum on perinatal outcome,' by C. Baron et al, published in `American Journal of Obstetrics and Gynecology.' Presence of oligohydramnios and risk of cesarean delivery; Incidence of meconium-stained amniotic fluid;...

  • The waiting game. Dahlen, Hannah // Australian Parents;Oct/Nov2007, p40 

    The article discusses issues related to pregnancy and childbirth. When a woman becomes pregnant, she is given an estimated date of delivery or confinement, which is often written as EDD or EDC. Some women like to try natural methods of induction as a first option when they are overdue. Babies...

  • the truth about labor. Kane, Susan // Baby Talk;Jun/Jul2007, Vol. 72 Issue 5, p5 

    The article presents the author's experience of undergoing induced labor. She says, when she was pregnant with her daughter, she was afraid the doctor would end up inducing her labor. She told her obstetrician that she prefered a cesarean section over induced labor. However, her doctor had to...

  • Rethinking induction and VBAC. Lockwood, Charles J.; Kaplan, Stanley H. // Contemporary OB/GYN;Nov2001, Vol. 46 Issue 11, p10 

    Editorial. Discusses the increase in incidence of vaginal birth after cesarean delivery (VBAC). Actions taken by healthcare professionals to decrease primary cesarian delivery rate; Use of hysterectomy for women undergoing VBAC; Risk associated with the use of Pitocin; Benefits of an induction...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics