The promise and perils of interpreting genetic associations in Crohn's disease

Trinh, T. T.; Rioux, J. D.
October 2005
Gut;Oct2005, Vol. 54 Issue 10, p1354
Academic Journal
Focuses on the genetic associations of Crohn's disease; Report that extended analyses of inflammatory bowel disease susceptibility loci is advisable before definitive conclusions about their causative role can be drawn; Merikangas,5 can be View that genetic studies can be powerful tools for identifying causal genes in common human diseases; Information that genome wide linkage analysis has been an extremely successful method for mapping rare but highly penetrant genes in monogenic disorders.


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