Review: Several pharmacologic therapies promote modest weight loss

Kennel, Kurt A.
September 2005
ACP Journal Club;Sep/Oct2005, Vol. 143 Issue 2, p50
Academic Journal
The article presents information about the pharmacologic treatment of obesity. Researchers selected randomized controlled trials that evaluated pharmaceutical agents for weight loss in patients with body mass index. Study quality was assessed using the 5-point Jadad scale and considered study design, method of random assignment, blinding, and withdrawal. The studies meeting inclusion criteria were 3 existing meta-analyses evaluating sibutramine, phentermine, and diethylpropion, and 47 randomized clinical trials that evaluated orlistat, bupropion, topiramate, and fluoxetine.


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