Alendronate reduced clinical and radiographic vertebral fractures in postmenopausal women with osteopenia

Adachi, Rick
September 2005
ACP Journal Club;Sep/Oct2005, Vol. 143 Issue 2, p46
Academic Journal
The article presents information about a study on the effect of alendronate on vertebral fracture (VF) in women with osteopenia. Researches carried out placebo-controlled trial. The subjects of the trial were 3737 aged between 55 to 80 years who had been postmenopausal for over two years. This study provides evidence that treatment with alendronate in this defined range of osteopenic patients prevents incident fractures in those who have prevalent VFs. In these patients, the relative risk reduction is 63 per cent for clinical VF and 44 per cent for radiographic VF, corresponding to a number needed to treat of 185 and 83, respectively; this is also in keeping with what one might expect in a population at lower risk.


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