Review: Mixed signals from trials concerning pharmacologic prevention of type 2 diabetes mellitus

Kenealy, Tim; Arroll, Bruce
September 2005
ACP Journal Club;Sep/Oct2005, Vol. 143 Issue 2, p44
Academic Journal
The article focuses on a study by researcher R. Padwal and colleagues, which reports on the pharmacologic prevention of type 2 diabetes mellitus. The study found that in patients with type 2 diabetes mellitus, some oral hypoglycemic agents and antiobesity drugs reduce the incidence of diabetes, but the findings are inconsistent and many studies have low patient follow-up or show high drug-related gastrointestinal adverse effects. It is concluded that no single agent is a clear choice for preventing diabetes in patients with impaired glucose tolerance.


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