Recombinant activated factor VII given within 4 hours of intracerebral hemorrhage reduced hematoma growth

Basile, Vincenzo S.; Silver, Frank L.
September 2005
ACP Journal Club;Sep/Oct2005, Vol. 143 Issue 2, p34
Academic Journal
The article presents an answer to a question related to the reduction of hematoma growth due to recombinant activated factor VII (rFVIIa) given within 4 hours of intracerebral hemorrhage. In this study, 63% of patients were treated within 3 hours after symptom onset. Growth in the volume of ICH was reduced more by rFVIIa than placebo. Among specific rFVIIa dose groups, the highest dose but not the lower doses or 80 reduced the volume of ICH more than placebo. The relatively small number of patients in this trial may account for imbalances in baseline characteristics, which may have biased the results in favor of treatment.


Related Articles

  • Effect of Intravenous Albumin Administration on HEMATOM Volume after Hemorrhagic Stroke. Ehsan Mohammadianinejad, Seyed; majdinasab, Nastaran; Shalilahmadi, Davood; Shirali, Amir; Oghbaei, Morteza // Jundishapur Scientific Medical Journal;2013, Vol. 12 Issue 4, p1 

    Background and Objective: The aim of this study was to evaluate the effect of albumin in hematom volume after hemorrhagic stroke. Subjects and Methods: The study was conducted in a randomized clinical trial; patients with hemorrhagic stroke in 24 hours of onset were included. Patients were...

  • Influence of the Placebo Effect upon the Healing Process. Squire, Carol // Positive Health;Apr2002, Issue 75, p27 

    Focuses on the influence of placebo effect in the healing process. Dependence of allopathic medicine to the placebo response; Assumption on the therapeutic effects of the placebo; Belief of the patient to the effectivity of a placebo.

  • Ethical questions over clinical use of placebo.  // Australian Journal of Pharmacy;May2009, Vol. 90 Issue 1068, p79 

    The article highlights some ethical questions over the clinical use of placebo treatments.

  • The Entity of Hemorrhagic Necrosis of the Intestine. LeVine, Michael A. // American Journal of Gastroenterology;Nov1970, Vol. 54 Issue 5, p490 

    Hemorrhagic mucosal necrosis is briefly reviewed with reference to pathogenesis, microscopic and gross pathologic findings, clinical presentation and presently available therapy.

  • Placebo Therapy and the Law: Prescribe with Care*. Kapp, Marshall B. // American Journal of Law & Medicine;Winter83, Vol. 8 Issue 4, p371 

    The use of placebos by physicians for therapeutic purposes is a common part of clinical medical practice. This Article examines the legal and ethical ramifications of placebo prescription. In particular, ethical concerns are related to substantive legal theories that may be advanced to attack or...

  • Chronic expanding hematoma in the retroperitoneal space: a case report. Syuto, Takahiro; Hatori, Motoaki; Masashi, Nomura; Sekine, Yoshitaka; Suzuki, Kazuhiro // BMC Urology;2013, Vol. 13 Issue 1, p1 

    Background Chronic expanding hematoma is a rare condition that develops after surgery, trauma, or injury. It can also develop at any location in the body in the absence of trauma. Clinical findings and various diagnostic imaging modalities can aid in the differential diagnosis of this condition....

  • Subdural Hematoma. Hurwitz, Jeffrey // New England Journal of Medicine;12/11/97, Vol. 337 Issue 24, p1732 

    The article discusses the medical case of a seventy-six year-old patient experiencing hypertension and with a history of stroke reported headache, difficulty in walking, and appetite loss. A neurological examination showed slowed speech with disorientation, somnolence with right homonymous...

  • Establishing A Model of Supratentorial Hemorrhage in the Piglet. Yuanllong Shi; Zai Wang Li; SuMing Zhang; MinJie Xie; XiangWu Meng; JinZhi Xu; Na Liu; ZhouPing Tang // Tohoku Journal of Experimental Medicine;Jan2010, Vol. 220 Issue 1, p33 

    The most common site of hemorrhage is the basal ganglia, which exhibits the obvious neurological deficits. In the present study, we aimed to develop a model of supratentorial intracerebral hemorrhage (ICH) with neurological deficits in piglets (6.0 to 8.8 kg). A pediatric urinary catheter with...

  • No evidence that placebos have powerful clinical effects, study says. Gottlieb, Scott // BMJ: British Medical Journal (International Edition);06/02/2001, Vol. 322 Issue 7298, p1325 

    Reports that treatment with placebo shows no evidence of having powerful clinical effects, according a study conducted at the University of Copenhagen. Reservations by many physicians toward the clinical use of placebos; Details of the study, which tested primarily the clinical effects of...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics