Warfarin was not more effective than aspirin and increased adverse events in symptomatic intracranial arterial stenosis

Eikelboom, John W.
September 2005
ACP Journal Club;Sep/Oct2005, Vol. 143 Issue 2, p32
Academic Journal
The article presents an answer to a clinical question related to the comparison of effectiveness of warfarin with aspirin in patients with symptomatic intracranial arterial stenosis. In patients with symptomatic intracranial arterial stenosis, warfarin was not more effective than aspirin and increased the rates of all-cause death, major hemorrhage and myocardial infarction or sudden death. The high incidence of bleeding in patients treated with warfarin is surprising. This may be due to the broad definition of major bleeding. The high dose of aspirin used in this study may have selectively increased bleeding in patients treated with aspirin, reducing the difference between the 2 treatments.


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