TITLE

Strategic Leukofiltration in Cardiac Surgery

AUTHOR(S)
Gunaydin, S.; McCusker, K.; Vijay, V.
PUB. DATE
October 2005
SOURCE
Current Medicinal Chemistry - Cardiovascular & Hematological Age;Oct2005, Vol. 3 Issue 4, p323
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Systemic inflammatory response syndrome (SIRS) with activation of molecular cascades, cell activation, accumulation of interstitial fluid, organ dysfunction and, occasionally, organ failure is still a commonly recognized consequence of cardiac surgery. SIRS leads to costly complications and several strategies intended to ameliorate the symptoms that have been studied, including leukocyte reduction, using filtration. Although, the body of work suggests that leukoreduction attenuates SIRS, discrepancies remain within the literature. The recent literature is reviewed highlighting the areas where concordance is lacking. In our study, on the basis of indirect indicators of SIRS, platelet function by thromboelastography biomaterial evaluation by light and scanning electron microscopy, we present our conclusions regarding clinical outcomes and the role of leukofiltration.
ACCESSION #
18407613

 

Related Articles

  • Ischemic Intestinal Injury during Cardiopulmonary Bypass Does Not Show an Association with Neutrophil Activation. Jormalainen, M.; Vento, A. E.; Wartiovaara-Kautto, U.; Suojaranta-Ylinen, R.; Lauronen, J.; Paavonen, T.; Petäjä, J. // European Surgical Research;2009, Vol. 42 Issue 1, p59 

    Background: Neutrophil activation and tissue sequestration are crucial events in intestinal ischemia-reperfusion injury, but their role in the gut wall after clinical cardiopulmonary bypass (CPB) remains unclear. We tested whether local post-CPB inflammatory response in the gut wall would be...

  • Biomaterials in cardiopulmonary bypass. Courtney, J.M.; Zhao, X.; Qian, H. // Perfusion;1999, Vol. 14 Issue 4, p263 

    Discusses the clinical use of biomedical materials in cardiopulmonary bypass procedure. Blood response to biomaterials; Information on biomaterials; Process of polymer synthesis and modification.

  • Biomaterial development for cardiopulmonary bypass. Gourlay, T. // Perfusion;Sep2001, Vol. 16 Issue 5, p381 

    Cardiopulmonary bypass (CPB) is dependent on materials foreign to the patient for its successful application. When blood comes into contact with these so-called biomaterials, an inappropriate inflammatory response, which can be life-threatening in some patients, may develop. The reason for this...

  • Evaluation of blood components exposed to coated arterial filters in extracorporeal circuits. Hussaini, Bader E.; Treanor, Patrick R.; Healey, Nancy A.; Tilahun, Daniel; Srey, Rithy; Xiu-Gui Lu; Khuri, Shukri F.; Thatte, Hemant S. // Perfusion;Sep2009, Vol. 24 Issue 5, p317 

    Background: Biocompatible surfaces play an important role in the inflammatory response during cardiopulmonary bypass (CBP), with the arterial filter contributing a large surface area of the circuit. Different filter-coating materials designed to improve blood-filter biocompatibility are...

  • Myocardial protection: an expanding or contracting discipline? Wechsler, Andrew S.; Brockman, Stanley K. // Perfusion;Jul2003, Vol. 18 Issue 4, p139 

    For the past thirty years cardiac surgeons have had a unique opportunity to study the consequences of myocardial ischemia and reperfusion. With the advent of an ability to intervene in acute myocardial syndromes, cardiologists have vigorously joined that effort as have fundamental scientists....

  • Light and electron microscopic analyses for ischaemia-reperfusion lung injury in an ovine cardiopulmonary bypass model. Kim, W.G.; Lee, B-H.; Seo, J.W. // Perfusion;May2001, Vol. 16 Issue 3, p207 

    An experiment to study the role of contact-activation leukocyte sequestration in the formation of ischaemia-reperfusion injury (I-R injury) was carried out. The study was conducted using light and electron microscopic analyses in an ovine cardiopulmonary bypass (CPB) model using a membrane...

  • Strategic leukocyte depletion reduces pulmonary microvascular pressure and improves pulmonary status post-cardiopulmonary bypass. Olivencia-Yurvati, AH; Ferrara, CA; Tierney, N; Wallace, N; Mallet, RT // Perfusion;Jan2003 Supplement, Vol. 18, p23 

    Cardiopulmonary bypass (CPB) precipitates inflammation that causes marked pulmonary dysfunction. Leukocyte filtration has been proposed to reduce these deleterious effects. Other studies show an improvement with aprotinin. We proposed that a combination of these two therapies would...

  • Does cardiopulmonary bypass still represent a good investment? The biomaterials perspective. Gourlay, T.; Connolly, P. // Perfusion;Jul2003, Vol. 18 Issue 4, p151 

    Cardiopulmonary (CPB) bypass is 50 years old this year, and has undergone considerable change in that time, particularly with regard to developing technology. However, in recent years the routine application of CPB, as the treatment of choice for patients undergoing reparative heart surgery, has...

  • MINERVA.  // BMJ: British Medical Journal (International Edition);9/14/91, Vol. 303 Issue 6803, p658 

    Provides several updates on the global practice of medicine. Role of reperfusion injury in pressure sores; Concerns over the resistance of mosquitoes to DDT in India; Observation of high survival rate in heart-lung transplantation among children.

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics