Hyperperfusion on Perfusion Computed Tomography Following Revascularization for Acute Stroke

Nguyen, T. B.; Lum, C.; Eastwood, J. D.; Stys, P. K.; Hogan, M.; Goyal, M.
September 2005
Acta Radiologica;Sep2005, Vol. 46 Issue 6, p610
Academic Journal
Purpose: To describe the findings of hyperperfusion on perfusion computed tomography (CT) in four patients following revascularization for acute stroke. Material and Methods: In 2002–2003, among a series of 6 patients presenting with an acute stroke and treated with intra‐arterial thrombolysis, we observed the presence of hyperperfusion in 3 patients on the follow‐up CT perfusion. We included an additional patient who was treated with intravenous thrombolysis and who had hyperperfusion on the follow‐up CT perfusion. We retrospectively analyzed their CT perfusion maps. Cerebral blood volume (CBV) and cerebral blood flow (CBF) maps were compared between the affected territory and the normal contralateral hemisphere. Results: In the four patients, the mean CBV and CBF were 3.6±2.0 ml/100 g and 39±25 ml/100 g/min in the affected territory compared to the normal side (mean CBV = 2.7±2.1 ml/100 g, mean CBF = 27±23 ml/100 g/min). There was no intracranial hemorrhage in the hyperperfused territories. At follow‐up CT, some hyperperfused brain areas progressed to infarction, while others retained normal white to gray matter differentiation. Conclusion: CT perfusion can demonstrate hyperperfusion, which can be seen in an ischemic brain territory following recanalization.


Related Articles

  • Perfusion CT in acute stroke: prediction of vessel recanalization and clinical outcome in intravenous thrombolytic therapy. Kloska, Stephan P.; Dittrich, Ralf; Fischer, Tobias; Nabavi, Darius G.; Fischbach, Roman; Seidensticker, Peter; Osada, Nani; Ringelstein, E. Bernd; Heindel, Walter // European Radiology;Oct2007, Vol. 17 Issue 10, p2491 

    This study evaluated perfusion computed tomography (PCT) for the prediction of vessel recanalization and clinical outcome in patients undergoing intravenous thrombolysis. Thirty-nine patients with acute ischemic stroke of the middle cerebral artery territory underwent intravenous thrombolysis...

  • Early CT scan predicts post-stroke response to thrombolytic therapy.  // Modern Medicine;Feb98, Vol. 66 Issue 2, p26 

    Discusses the abstract `Acute Stroke: Usefulness of Early CT Findings Before Thrombolytic Therapy,' by R. von Krummer, K.L. Allen, R. Holle et al., which appeared in the November 1997 issue of `Radiology.'

  • Perfusion CT helps decision making for thrombolysis when there is no clear time of onset. Hellier, K. D.; Hampton, J. L.; Guadagno, J. V.; Higgins, N. P.; Antoun, N. M.; Day, D. J.; Gillard, J. H.; Warburton, E. A.; Baron, J-C. // Journal of Neurology, Neurosurgery & Psychiatry;Mar2006, Vol. 77 Issue 3, p417 

    Current guidelines on thrombolysis post stroke with recombinant tissue plasminogen activator (rt-PA) exclude its use where time of onset is unknown, thus denying some patients potentially beneficial treatment. Contrast enhanced perfusion computed tomography (pCT) imaging can be used together...

  • Acute stroke: Early thrombolysis can improve neurologic function.  // Geriatrics;Mar95, Vol. 50 Issue 3, p14 

    Reports that thrombolytic treatment of moderate to severe ischemic stroke reduces neurologic deficits in appropriately selected patients, according to results from the European Cooperative Acute Stroke Study (ECASS). Response of patients to thrombolytic treatment with t-PA (Activase).

  • Comparison of Coronary Angiographic Features and Oral Dipyridamole Thallium 201 Tomography. Jain, Avanindra; Myers, G. Hunter; Rowe, Mathew W.; Dehmer, Gregory J.; Robinson, Debra S. // Angiology;Feb1991, Vol. 42 Issue 2, p99 

    Coronary angiography and left ventriculography is commonly used to identify those patients with incomplete infarctions and therefore, a need for revascularization. The authors compared coronary angiography and left ventriculography with thalliumm 201 tomography using oral dipyridamole to...

  • Regional Attenuation without Delta (RAWOD): A distinctive EEG pattern that can aid in the diagnosis and management of severe acute ischemic stroke. Schneider, Anita L.; Jordan, Kenneth G. // American Journal of Electroneurodiagnostic Technology;Jun2005, Vol. 45 Issue 2, p102 

    Acute thrombolysis with recombinant tissue plasminogen activator (tPA) is the only treatment of proven effectiveness in acute ischemic stroke (AIS). Cerebral edema (CE) is the most feared and fatal complication of AIS. For both of these conditions, patient selection for treatment and timing of...

  • Mechanical Reperfusion for Patients with MI. Wellbery, Caroline // American Family Physician;5/15/2004, Vol. 69 Issue 10, p2461 

    Discusses the study "Mortality Benefit of Immediate Revascularization of Acute ST-Segment Elevation Myocardial Infarction in Patients With Contraindications to Thrombolytic Therapy. A Propensity Analysis," by M. Grzybowski et al., from the October 8, 2003 issue of the "Journal of American...

  • Inducible ischemia after MI. Platzner, Anne; Saver, Barry // Journal of Family Practice;Nov1997, Vol. 45 Issue 5, p375 

    The article presents a study which examined the potential benefits of delayed revascularization after thrombolysis. Thrombolysis enhances the survival of acute myocardial infarction (AMI) patients. The delayed invasive therapy after thrombolysis for AMI minimizes the possibility of developing...

  • Advancing Stroke Therapeutics Through Genetic Understanding. Ross, O. A.; Worrall, B. B.; Meschia, J. F. // Current Drug Targets;Jul2007, Vol. 8 Issue 7, p850 

    Stroke is a complex neurological disorder that most likely results from an intricate interplay between lifestyle, environment and genetics. Genes can influence susceptibility to stroke, alter responses to pharmacotherapy, and affect disease outcome. Recently, common variations within the PDE4D...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics