TITLE

APOPTOSIS AND COLORECTAL CANCER

AUTHOR(S)
Watson, A. J. M.
PUB. DATE
December 2004
SOURCE
Gut;Dec2004, Vol. 53 Issue 12, p1701
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
This article reports on recent medical advances related to apoptosis and colorectal cancer. Apoptosis, the morphologically defined form of programmed cell death, is a cellular process that is of tremendous current interest to clinicians who study and treat cancer. Nowhere is this truer than in the area of colorectal cancer and its management. Abnormalities in apoptotic function contribute to both the pathogenesis of colorectal cancer and its resistance to chemotherapeutic drugs and radiotherapy, both of which act, at least in part, by killing cells. A remarkable feature of apoptosis is that the essential features of its regulation are conserved in all metazoans. Study of cell death pathways in the nematode worm Caenorhabditis elegans has proved enormously helpful in identifying the key elements of cell death mechanisms.
ACCESSION #
18384804

 

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