- Anti-tumor necrosis factor treatment restores the gut barrier in Crohnâ€™s disease Suenaert, Peter; Bulteel, Veerle; Lemmens, Liesbeth; Noman, Maja; Geypens, Benny; Assche, Gert Van; Geboes, Karel; Ceuppens, Jan L.; Rutgeerts, Paul // American Journal of Gastroenterology;Aug2002, Vol. 97 Issue 8, p2000
OBJECTIVES:A primary defect of the tight junctions and, hence, increased intestinal epithelial permeability has been proposed as a basic pathogenic event in Crohnâ€™s disease. Challenge of the mucosal immune system by the commensal gut flora would then result in chronic inflammation....
- Increased Intestinal Permeability in Patients with Crohn's Disease and Their Relatives. Hollander, Daniel; Vadheim, Constance M.; Brettholz, Edward; Pettersen, Gloria M.; Delahunty, Thomas; Rotter, Jerome I. // Annals of Internal Medicine;Dec86, Vol. 105 Issue 6, p883
Presents a study that examined the role of increase intestinal permeability in patients with Crohn's disease. Causes of Crohn's disease; Methodology of the study; Discussion on the result of the study.
- Slipping the barrier: how variants in CARD 15 could alter permeability of the intestinal wall and population health. Schreiber, S. // Gut;Mar2006, Vol. 55 Issue 3, p308
The increased intestinal permeability in Crohn's disease is associated with the presence of variants in the CARD15 gene that are regarded as causative for Crohn's disease, suggesting a genetic rather than an environmental background for intestinal Barrier dysfunction in Crohn's disease.
- Intestinal permeability in children with Crohn's disease. Pearson, A.D.J.; Eastham, E.J.; Laker, M.F.; Craft, A.W.; Nelson, R. // British Medical Journal (Clinical Research Edition);7/3/1982, Vol. 285 Issue 6334, p20
Investigates the intestinal permeability in children with Crohn's disease and celiac disease in Great Britain. Administration of mannitol and lactulose to measure the intestinal permeability; Increase in permeability in patients with Crohn's disease due to lactulose; Differences between...
- The Effect of Cigarette Smoke Exposure on the Development of Inflammation in Lungs, Gut and Joints of TNFÎ”ARE Mice. Allais, Liesbeth; Kumar, Smitha; Debusschere, Karlijn; Verschuere, Stephanie; Maes, Tania; De Smet, Rebecca; Conickx, Griet; De Vos, Martine; Laukens, Debby; Joos, Guy F.; Brusselle, Guy G.; Elewaut, Dirk; Cuvelier, Claude A.; Bracke, Ken R. // PLoS ONE;11/2/2015, Vol. 10 Issue 10, p1
The inflammatory cytokine TNF-Î± is a central mediator in many immune-mediated diseases, such as Crohnâ€™s disease (CD), spondyloarthritis (SpA) and chronic obstructive pulmonary disease (COPD). Epidemiologic studies have shown that cigarette smoking (CS) is a prominent common risk factor...
- Too soon to blame measles for gut disease. Bell, Ruth // New Scientist;12/4/93, Vol. 140 Issue 1902, p18
Reports on Royal Free Hospital's Andrew Wakefield's suggestion that the measles virus is causing Crohn's disease. Link between Crohn's and measles vaccine; Finding evidence of measle virus in blood vessels supplying the gut of people with Crohn's; Lack of a consistent evidence; Criticisms.
- CORRECTION. // Gut;May2005, Vol. 54 Issue 5, p734
Presents a correction for the article "Impact of the Increasing Use of Immunosuppressants in Crohn's Disease on the Need for Intestinal Surgery" that was published in a 2005 issue of the periodical "Gut."
- Crohn's Disease and Intestinal Bacteria. Klotter, Jule // Townsend Letter;Jun2013, Issue 359, p20
The article reports on the connection between potentially disease-causing bacteria called pathobionts and Crohn's disease (CD). According to Dutch researcher Hermie J. M. Harmsen and colleagues, people with CD experience chronic gut inflammation because of a heightened immune response to...
- Vedolizumab as a Treatment for Crohn's Disease and Ulcerative Colitis. Ha, Christina; Kornbluth, Asher // Gastroenterology & Hepatology;Dec2014, Vol. 10 Issue 12, p793
The management of Crohn's disease and ulcerative colitis has become increasingly complex. With the current utilization of immunosuppressive therapies earlier in the disease course for patients presenting with moderate to severe disease, there is a great need for additional biologic agents...
- Intestinal-Specific TNFÎ± Overexpression Induces Crohnâ€™s-Like Ileitis in Mice. Bamias, Giorgos; Dahman, Mohamed I.; Arseneau, Kristen O.; Guanzon, Mitchell; Gruska, Dennis; Pizarro, Theresa T.; Cominelli, Fabio // PLoS ONE;Aug2013, Vol. 8 Issue 8, p1
Background and Aim:Human and animal studies have clearly established tumor necrosis factor (TNF)Î± as an important mediator of Crohnâ€™s disease pathogenesis. However, whether systemic or only local TNFÎ± overproduction is required for the development of chronic intestinal inflammation...