Modulation of human dendritic cell phenotype and function by probiotic bacteria
- In this Issue. // Mucosal Immunology (1933-0219);Jan2014, Vol. 7 Issue 1, p1
An introduction is presented which discusses various reports within the issue including mucosal healing in patients with inflammatory bowel diseases (IBD), lung immunization for tuberculosis, and the distribution of dendritic cells in the oral mucosa.
- Immortalized Dendritic Cell Line with Efficient Cross-Priming Ability Established from Transgenic Mice Harboring the Temperature-Sensitive SV40 Large T-Antigen Gene. Ebihara, Shin; Endo, Shota; Ito, Kozue; Ito, Yumi; Akiyama, Kenichi; Obinata, Masuo; Takai, Toshiyuki // Journal of Biochemistry;Sep2004, Vol. 136 Issue 3, p321
The uptake of an antigen and its presentation to specific T cells by dendritic cells (DCs) is a primary event in initiation of humoral and cellular immune responses as well as the induction of cytotoxic T cells (CTLs). DCs are induced by culturing bone marrow cells in the presence of GM-CSF....
- Direct contact of platelets and their released products exert different effects on human dendritic cell maturation. Hamzeh-Cognasse, Hind; Cognasse, Fabrice; Palle, Sabine; Chavarin, Patricia; Olivier, Thomas; Delézay, Olivier; Pozzetto, Bruno; Garraud, Olivier // BMC Immunology;2008, Vol. 9, Special section p1
Background: Dendritic cells (DCs) are antigen presenting cells capable of inducing innate and adaptive immune responses. According to the stimulus and their maturation state, DCs induce immunogenic or tolerogenic responses. Platelets (PLTs), which are involved in haemostasis and inflammation,...
- MHC Class I+ /II- Dendritic Cells Induce Hapten-Specific Immune Responses In Vitro and In Vivo. Kolesaric, Andrea; Stingl, Georg; Elbe-Bürger, Adelheid // Journal of Investigative Dermatology;Oct97, Vol. 109 Issue 4, p580
Activation requirements and biologic properties of hapten-specific, major histocompatibility complex class I-restricted CD8+T lymphocytes are not fully understood. To address this issue, a novel CD45+ /major histocompatibility complex class I+(H-2k)/II-/CD80+ dendritic cell line, termed 80/1,...
- Dendritic Cell Editing by Activated Natural Killer Cells Results in a More Protective Cancer-Specific Immune Response. Morandi, Barbara; Mortara, Lorenzo; Chiossone, Laura; Accolla, Roberto S.; Mingari, Maria Cristina; Moretta, Lorenzo; Moretta, Alessandro; Ferlazzo, Guido // PLoS ONE;Jun2012, Vol. 7 Issue 6, p1
Over the last decade, several studies have extensively reported that activated natural killer (NK) cells can kill autologous immature dendritic cells (DCs) in vitro, whereas they spare fully activated DCs. This led to the proposal that activated NK cells might select a more immunogenic subset of...
- Î²(sub2) integrins are required for skin homing of primed T cells but not for priming naive T cells. Grabbe, Stephan; Vagra, Georg; Beissert, Stefan; Steinert, Meike; Pendl, Gunther; Seeliger, Stephan; Bloch, Wilhelm; Peters, Thorsten; Schwartz, Thomas; Sunderkotter, Cord; Scharffetter-Kochanek, Karin // Journal of Clinical Investigation;1/15/2002, Vol. 109 Issue 2, p183
Presents a study that investigated the capacity of T cells and dendritic cells to extravasate into inflamed tissue, and used various cutaneous immune responses as experimental models. Methods; Results; Discussion.
- Fuel feeds function: energy metabolism and the T-cell response. Fox, Casey J.; Hammerman, Peter S.; Thompson, Craig B. // Nature Reviews Immunology;Nov2005, Vol. 5 Issue 11, p844
Ligation of antigen receptors at the surface of lymphocytes initiates a transcriptional and translational response that is required for cellular proliferation and effector function. By contrast, co-stimulatory-molecule ligation contributes to the immune response by allowing the uptake and...
- Mesenchymal Stem Cells in IBD: unMaSCing Their Therapeutic Mechanisms. Scaldaferri, Franco; Vetrano, Stefania // Digestive Diseases & Sciences;Jul2015, Vol. 60 Issue 7, p1873
No abstract available.
- HVEM Signalling Promotes Colitis. Schaer, Corinne; Hiltbrunner, Stefanie; Ernst, Bettina; Mueller, Christoph; Kurrer, Michael; Kopf, Manfred; Harris, Nicola L. // PLoS ONE;2011, Vol. 6 Issue 4, p1
Background: Tumor necrosis factor super family (TNFSF) members regulate important processes involved in cell proliferation, survival and differentiation and are therefore crucial for the balance between homeostasis and inflammatory responses. Several members of the TNFSF are closely associated...