TITLE

NOD2 mutations and Crohn's disease: are Paneth cells and their antimicrobial peptides the link?

AUTHOR(S)
Grimm, M. C.; Pavli, P.
PUB. DATE
December 2004
SOURCE
Gut;Dec2004, Vol. 53 Issue 12, p1558
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Comments on the relation between NOD2 mutations and Crohn's disease. Evidence that CARD15/NOD2 variants in Crohn's disease are associated with diminished mucosal α-defensin production, resulting in impaired innate immunity; Information on paneth cells; link between intestinal inflammation and paneth cell number; Discussion on defensins, family of small cationic antimicrobial peptides; Implications of defensin deficiencies.
ACCESSION #
18384779

 

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