NOD2 mutations and Crohn's disease: are Paneth cells and their antimicrobial peptides the link?

Grimm, M. C.; Pavli, P.
December 2004
Gut;Dec2004, Vol. 53 Issue 12, p1558
Academic Journal
Comments on the relation between NOD2 mutations and Crohn's disease. Evidence that CARD15/NOD2 variants in Crohn's disease are associated with diminished mucosal α-defensin production, resulting in impaired innate immunity; Information on paneth cells; link between intestinal inflammation and paneth cell number; Discussion on defensins, family of small cationic antimicrobial peptides; Implications of defensin deficiencies.


Related Articles

  • NOD2 mutations and Crohn's disease: are Paneth cells and their antimicrobial peptides the link? Grimm, M. C.; Pavli, P. // Gut;Nov2004, Vol. 53 Issue 11, p1558 

    The article examines if there is an association of Paneth cells and their antimicrobial peptides in NOD2 mutations and Crohn's disease. According to the authors, there is manifestation that NOD2 variants in Crohn's disease are associated with atrophied mucosal Α-defensin production, leading...

  • SHIP deficiency causes Crohn's disease-like ileitis. William G Kerr // Gut;Feb2011, Vol. 60 Issue 2, p177 

    BACKGROUND: Inflammatory bowel disease (IBD) can arise from genetic mutations that compromise intestinal epithelial cell integrity or immune regulation. SHIP has previously been shown to play a pivotal role in limiting the number of immunoregulatory cells and their function. AIM: To determine...

  • Autophagy in Inflammatory Diseases. Choi, Alexander J. S.; Ryter, Stefan W. // International Journal of Cell Biology;2011, Vol. 2011, p1 

    Autophagy provides a mechanism for the turnover of cellular organelles and proteins through a lysosome-dependent degradation pathway. During starvation, autophagy exerts a homeostatic function that promotes cell survival by recycling metabolic precursors. Additionally, autophagy can interact...

  • A potential role of pathobionts in the pathogenesis of pediatric inflammatory bowel disease. Schippa, Serena; Iebba, Valerio; Totino, Valentina; Santangelo, Floriana; Lepanto, Mariastefania; Alessandri, Claudia; Nuti, Federica; Viola, Franca; Di Nardo, Giovanni; Cucchiara, Salvatore; Longhi, Catia; Conte, Maria Pia // Canadian Journal of Microbiology;Apr2012, Vol. 58 Issue 4, p426 

    Through genomic analysis of mucosa-associated strains, we found a close genetic association among isolates from pediatric inflammatory bowel disease (IBD) patients. A specific E. coli pathovar, adherent-invasive E. coli (AIEC), was found in Crohn's disease (CD) adult patients - this pathovar has...

  • NOD-like receptors: Ancient sentinels of the innate immune system. Rosenstiel, P.; Jacobs, G.; Till, A.; Schreiber, S. // Cellular & Molecular Life Sciences;May2008, Vol. 65 Issue 9, p1361 

    NOD-like receptors (NLRs) comprise a family of cytosolic proteins that have been implicated as ancient cellular sentinels mediating protective immune responses elicited by intracellular pathogens or endogenous danger signals. Genetic variants in NLR genes have been associated with complex...

  • Induction and rescue of Nod2-dependent Th1-driven granulomatous inflammation of the ileum.  // Inflammatory Bowel Disease Monitor;2011, Vol. 11 Issue 3, p123 

    The article presents a study on the dysregulation of nucleotide-binding oligomerization domain containing 2 (NOD2) function in Paneth cells thru a receptor-interacting serine/threonine-protein 2 kinase (Rip2K)-dependent pathway. It notes that NOD2 function is required to control the microbiota...

  • NOD2 (CARD15) mutations in Crohn's disease are associated with diminished mucosal α-defensin expression. Wehkamp, J.; Harder, J.; Weichenthal, M.; Schwab, M.; Schäffeler, E.; Schlee, M.; Herrlinger, K. R.; Stallmach, A.; Noack, F.; Fritz, P.; M. Schröder, J.; Bevins, C. L.; Fellermann, K.; Stange, E. F. // Gut;Nov2004, Vol. 53 Issue 11, p1658 

    Background: Mutations in NOD2, a putative intracellular receptor for bacterial peptidoglycans, are associated with a subset of Crohn's disease but the molecular mechanism linking this protein with the disease pathogenesis remains unclear. Human a defensins (HD-5 and HD-6) are antibiotic effector...

  • Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production. Saitoh, Tatsuya; Fujita, Naonobu; Jang, Myoung Ho; Uematsu, Satoshi; Yang, Bo-Gie; Satoh, Takashi; Omori, Hiroko; Noda, Takeshi; Yamamoto, Naoki; Komatsu, Masaaki; Tanaka, Keiji; Kawai, Taro; Tsujimura, Tohru; Takeuchi, Osamu; Yoshimori, Tamotsu; Akira, Shizuo // Nature;11/13/2008, Vol. 456 Issue 7219, p264 

    Systems for protein degradation are essential for tight control of the inflammatory immune response. Autophagy, a bulk degradation system that delivers cytoplasmic constituents into autolysosomes, controls degradation of long-lived proteins, insoluble protein aggregates and invading microbes,...

  • NALP3: a key player in caspase-1 activation. Sutterwala, Fayyaz S.; Ogura, Yasunori; Zamboni, Dario S.; Roy, Craig R.; Flavell, Richard A. // Journal of Endotoxin Research;2006, Vol. 12 Issue 4, p251 

    The NLR (NACHT-LRR) family of proteins have been implicated in the regulation of immune responses and cell death pathways. Some NLR family members can form multiprotein complexes, called inflammasomes, involved in the activation of pro-inflammatory caspases. Mutations in the...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics