Full-Thickness Chest Wall Resection for Recurrent Breast Carcinoma: An Institutional Review and Meta-analysis

Pameijer, Colette R. J.; Smith, David; McCahill, Laurence E.; Bimston, David N.; Wagman, Lawrence D.; Ellenhorn, Joshua D. I.
September 2005
American Surgeon;Sep2005, Vol. 71 Issue 9, p711
Academic Journal
Locoregional recurrence of breast cancer can occur in up to 30 per cent of patients and has often been considered to indicate a poor prognosis. We reviewed our experience with full-thickness chest wall resection for recurrent breast cancer and conducted a meta-analysis of the English literature to determine patient characteristics and outcomes. Twenty-two women with isolated chest wall recurrence of breast cancer were treated between 1970 and 2000 at our institution. We reviewed their preoperative demographics, operative management and outcome, and combined our results with seven other English language studies. A majority of women (90%) underwent a mastectomy as initial management of their breast cancer. Only 18 per cent of patients had metastatic disease at the time of chest wall resection, and 71 per cent of patients had an R0 resection. The 5-year disease-free survival at City of Hope National Medical Center (COH) was 67 per cent and was 45 per cent for the entire group of 400 patients. The 5-year overall survival was 71 per cent for the COH group and 45 per cent for the entire group. Several studies reported prognostic factors, the most common being a better prognosis in patients with a disease-free interval greater than 24 months. Full-thickness chest wall resection for patients with isolated local recurrence of breast cancer can provide long-term palliation and even cure in some patients.


Related Articles

  • Implants Not Implicated in Cancer Recurrence.  // USA Today Magazine;Oct2005, Vol. 134 Issue 2725, p5 

    Discusses research being done on breast reconstruction with implants after mastectomy for breast cancer. Incidence of local breast cancer recurrence in reconstructed patients; Effect of breast implants on the early detection of cancer recurrence; Number of patients involved in the study who...

  • CITATIONS AND CLINICIANS' NOTES: TREATMENT - PRIMARY TREATMENT FOR OPERABLE DISEASE.  // Current Medical Literature: Breast Cancer;2005, Vol. 17 Issue 2, p50 

    Discusses research being done on the prognosis of patients who developed a local recurrence after surgery and radiotherapy for invasive breast cancer. Reference to a study by S. Galper and colleagues published in a 2005 issue of "International Journal of Radiation, Oncology, Biology and...

  • Study of time-course changes in annual recurrence rates for breast cancer: data analysis of 2,209 patients for 10 years post-surgery. Morihiko Kimura; Yasuhiro Yanagita; Tomomi Fujisawa; Tokihiro Koida // Breast Cancer Research & Treatment;Dec2007, Vol. 106 Issue 3, p407 

    Annual recurrence rates (ARR) are used to assess changes in the risk of breast cancer recurrence following surgery. In this retrospective study, ARR were calculated from the clinical records of 2,209breast cancer patients who had undergone surgery. The time-course changes of ARR associated with...

  • Improvement Needed for Mastectomy Outcomes Reporting.  // JNCI: Journal of the National Cancer Institute;Jan2011, Vol. 103 Issue 1, pNP 

    The article discusses research on the need for improved standards for outcome reporting in breast reconstruction. It references a study by Shelley Potter and colleagues, published in the December 3, 2010 online issue of the "Journal of the National Cancer Institute." Study authors discovered an...

  • Reporting Clinical Outcomes of Breast Reconstruction: A Systematic Review. Potter, S.; Brigic, A.; Whiting, P. F.; Cawthorn, S. J.; Avery, K. N. L.; Donovan, J. L.; Blazeby, J. M. // JNCI: Journal of the National Cancer Institute;Jan2011, Vol. 103 Issue 1, p31 

    Background Breast reconstruction after mastectomy for cancer requires accurate evaluation to inform evidence-based participatory decision making, but the standards of outcome reporting after breast reconstruction have not previously been considered. Methods We used extensive searches to identify...

  • Feasibility Study of Safe Breast Conservation in Large and Locally Advanced Cancers with Use of Radiopaque Markers to Mark Pre-Neoadjuvant Chemotherapy Tumor Margins. Aggarwal, Vivek; Agarwal, Gaurav; Lal, Punita; Krishnani, Narendra; Mishra, Anjali; Verma, Ashok K.; Mishra, Saroj K. // World Journal of Surgery;Dec2008, Vol. 32 Issue 12, p2562 

    The lack of objective documentation of pre-neoadjuvant chemotherapy (NACT) margins after chemotherapy is a major constraint in performing safe breast-conserving surgery (BCS) in patients with locally advanced breast cancer (LABC). Using a novel method of marking pre-NACT tumor margins with...

  • The Breast Cancer Research Stamp: A KP Physician's Global Crusade.  // Profiles in Diversity Journal;Jan/Feb2008, Vol. 10 Issue 1, p43 

    The article focuses on the effort of Ernie Bodai, clinical professor of surgery and director of the Breast Health Center at Kraiser Permanente in Sacramento, California. He has been a cancer crusader, having treated thousands of breast cancer patients in his more than 20 years with Kaiser...

  • Whether drainage should be used after surgery for breast cancer? A systematic review of randomized controlled trials. He, Xiao-Dong; Guo, Zhi-Hui; Tian, Jin-Hui; Yang, Ke-Hu; Xie, Xiao-Dong // Medical Oncology;Dec2011, Vol. 28, p22 

    A systematic review of randomized controlled trials (RCTs) was conducted to evaluate whether patients benefit from the suction drainage after axillary lymph node dissection (ALND) in breast cancer surgery. RCTs of drainage versus no drainage after ALND in women with breast cancer were retrieved...

  • The importance of margins status after breast conservative surgery and radiotherapy in node positive patients: a follow-up of 10-15 years. Besana-Ciani, Isabella; Greenall, Michael J. // International Seminars in Surgical Oncology;2008, Vol. 5, Special section p1 

    Background: Margin status is the main factor determining local recurrence (LR) after wide excision and radiotherapy for breast cancer. The aim of the study is to evaluate if positive margins are as great a risk factor for LR in node-positive as in node-negative patients, since the major risk in...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics