Clinical studies of 13C-urea breath test in Japan

Kato, Mototsugu; Asaka, Mashiro; Ohaka, Shuichi; Toyota, Takavosii
November 1998
Journal of Gastroenterology;1998 Supplement 10, Vol. 33, p36
Academic Journal
The urea breath test (UBT) using isotope carbon is a non-invasive method for diagnosing hr. pylori infection. In Japan, only 13C-UBT using a stable isotope is available, since the clinical use of radioactive isotope 14C-compounds is prohibited. Since there is no worldwide standard protocol for the 13C-UBT, it is therefore important to standardize this test to obtain a cheap, easy, reproducible method. Factors affecting the outcome of 13C-UBT values include sampling times and frequency, the amount of 13C-urea, the cut-off value, the avoidance of oral urease activity, and changes in gastric emptying times and 13C-urea distribution. Mouth rinsing reduces false-positive results due to oral urease activity, particularly within 20 min after ingestion of 13C-urea. A Japanese multicenter trial has shown that the diagnostic utility of 13C-UBT is superb, with the cut-off value 2.5‰ in 20-min samples after ingestion of 100 mg 13C-urea. The 13C-UBT is a very useful method for diagnosing H. pylori infection.


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