TITLE

Helicobacter pylori infection and molecular changes in gastric carcinogenesis

AUTHOR(S)
Ebert, Matthias P. A.; Schandl, Laszlo; Malfertheiner, Peter
PUB. DATE
June 2002
SOURCE
Journal of Gastroenterology;2002 Supplement 13, Vol. 37, p45
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
In recent years there has been much progress in understanding the pathogenesis of gastric cancer. The role of individual factors in gastric carcinogenesis continues to be debated and is also subject to further analysis, hi addition to the activation of oncogenes and the inactivation of tumor suppressor genes, alteration of adhesion molecules seems to be critical for the development of gastric cancer. Helicobacter pylori has been linked to an increased risk of developing gastric cancer, and the molecular changes induced by H. pylori are currently being investigated. Recent studies indicate that H. pylori induces cell proliferation and apoptosis during the early phase of chronic inflammation of the gastric mucosa, whereas in the malignant transformation of the gastric mucosa apoptosis is inhibited and adhesion of gastric epithelial cells is impaired. This review focuses on the role of H. pylori in the development of molecular changes in gastric cancer and its preneoplastic lesions.
ACCESSION #
18318390

 

Related Articles

  • Identification of gastric cancer risk markers that are informative in individuals with past H. pylori infection. Nanjo, Sohachi; Asada, Kiyoshi; Yamashita, Satoshi; Nakajima, Takeshi; Nakazawa, Kazuyuki; Maekita, Takao; Ichinose, Masao; Sugiyama, Toshiro; Ushijima, Toshikazu // Gastric Cancer;Oct2012, Vol. 15 Issue 4, p382 

    Background: Epigenomic damage induced by Helicobacter pylori infection is accumulated in gastric mucosae before the development of malignancy. In individuals without current H. pylori infection, DNA methylation levels of specific CpG islands (CGIs) are associated with gastric cancer risk....

  • Long-term Helicobacter pylori infection and the development of atrophic gastritis and gastric cancer in Japan. Takahashi, Shini'ichi // Journal of Gastroenterology;2002 Supplement 13, Vol. 37, p24 

    The incidence of gastric cancer and the prevalence of Helicobacter pylori are high in Japan, so it is an important issue whether long-term H. pylori infection leads to chronic atrophic gastritis, considered one of the precursors of gastric cancer. We have reported that the grade of atrophy was...

  • Triple eradication therapy counteracts pathomorphological and functinal impairment caused by Helicobacter pylori (Hp) infection in Mongolian gerbils. Pajdo, R.; Brzozowski, T.; Konturek, P.C.; Kwiecien, S.; Drozdowicz, D.; Ptak, A.; Konturek, S.J.; Bielanski, W.; Hahn, E.G.; Szczyrk, U. // Gut;Sep2002 Supplement 2, Vol. 51, pA40 

    Background: Hp infection in Mongolian gerbils is an experimental model of gastric carcinogenesis. It remains unknown whether anti-Hp triple therapy influences pathological and functional aspects accompanying Hpinduced cancer cascade especially gastric acid secretion, gastric blood flow (GBF) and...

  • Genetic Variation in PSCA and Risk of Gastric Advanced Preneoplastic Lesions and Cancer in Relation to Helicobacter pylori Infection. Rizzato, Cosmeri; Kato, Ikuko; Plummer, Martyn; Muñoz, Nubia; Canzian, Federico // PLoS ONE;Sep2013, Vol. 8 Issue 9, p1 

    SNPs in the Prostate Stem Cell Antigen (PSCA) gene have been found associated with gastric cancer (GC) risk in a genome-wide association study. This association has been replicated in several populations. In this study we assessed the impact of PSCA genotype on the risk of advanced gastric...

  • Methylation of p16INK4A and p57KIP2 are involved in the development and progression of gastric MALT lymphomas. Ki Ouk Min; Eun Joo Seo; Hi Jeong Kwon; Eui Jin Lee; Won Il Kim; Chang Suk Kang; Kyoung-Mee Kim // Modern Pathology;Jan2006, Vol. 19 Issue 1, p141 

    p16INK4A and p57KIP2 are inhibitors of cyclin-dependent kinases and their inactivation by methylation has been reported as a major tumorigenic mechanism in tumors. To examine whether methylation of p16INK4A and p57KIP2 is involved in the development and progression of gastric MALT lymphomas, 24...

  • Gastric cancer. Paul Lochhead; Emad M. El-Omar // British Medical Bulletin;Mar2008, Vol. 85 Issue 1, p87 

    Background Gastric cancer remains a major cause of mortality and morbidity worldwide, and the total number of gastric cancer cases is predicted to rise as a result of population growth. The pathogenesis of gastric cancer represents a paradigm for microbially induced and inflammation-driven...

  • Ectopic expression of guanylyl cyclase C and endogenous ligand guanylin correlates significantly with Helicobacter pylori infection in gastric carcinogenesis. Zhang, Jian-Feng; Mao, Zhen-Biao; Li, Zeng-Li; Xue, Shi-Min; Zhu, Hui-Jun; Zhang, Hong; Ni, Run-Zhou // Medical Oncology;Sep2012, Vol. 29 Issue 3, p1748 

    The molecular mechanisms leading to gastric carcinogenesis still remain unclear. Recently, several studies demonstrated that over-expression of guanylyl cyclase C (GCC) has been detected in intestinal-type gastric cancer (GC) and precursor lesions. Our objective was to explore the expression...

  • Stromal Cells Induce Th17 during Helicobacter pylori Infection and in the Gastric Tumor Microenvironment. Pinchuk, Irina V.; Morris, Katherine T.; Nofchissey, Robert A.; Earley, Rachel B.; Jeng-Yih Wu; Ma, Thomas Y.; Beswick, Ellen J. // PLoS ONE;Jan2013, Vol. 8 Issue 1, Special section p1 

    Gastric cancer is associated with chronic inflammation and Helicobacter pylori infection. Th17 cells are CD4+ T cells associated with infections and inflammation; but their role and mechanism of induction during carcinogenesis is not understood. Gastric myofibroblasts/fibroblasts (GMF) are...

  • Helicobacter pyloriinfection and gastric cancer. Sugiyama, Toshiro; Asaka, Masahiro // Medical Electron Microscopy;Sep2004, Vol. 37 Issue 3, p149 

    Helicobacter pylori infection has an association with histological gastritis, gastric atrophy, gastric cancer, and mucosa-associated lymphoid tissue (MALT) lymphoma in the stomach. Gastric cancer occurs in only a minority of infected individuals, however. Such clinical diversities are caused by...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics