Idiopathic membranous nephropathy in children

Olbing, Hermann; Greifer, Ira; Bennett, Boyce P.; Bernstein, Jay; Spitzer, Adrian
January 1973
Kidney International;Jan1973, Vol. 3 Issue 1, p381
Academic Journal
Based on evidence obtained mainly from adult patients, membranous nephropathy is generally described as a progressisve disease that leads to renal insufficiency. This paper presents the course of the disease in a group of 9 children ranging in age between 2 and 16 years at clinical onset. Three of these children, all older than 10 years, two of them hypertensive when First seen, deteriorated rapidly. Another group of three patients, younger than 9 years and normotensive at onset, followed a benign course characterized by prolonged remissions, preservation of normal kidney function and in one of them morphological evidence of healing. Yet another group of patients, ranging in age between 8 arid 14 years and normotensive, maintained a normal function of the kidneys alter 8, 3½ and 1 yr of continuous proteinuria anti hematuria. No progression was detectable on the renal biopsies in two of these patients, performed alter several years of observation. The relative benign course of the disease in the majority of our patients and the morphological evidence of healing in one of them suggest a better prognosis than that reported by previous investigators. This might be particularly true for patients developing the disease at a very young age.


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