TITLE

Redistribution of renal blood flow in acute and chronic reduction of renal mass

AUTHOR(S)
Carriere, Serge; Wong, Norman L. M.; Dirks, John H.
PUB. DATE
January 1973
SOURCE
Kidney International;Jan1973, Vol. 3 Issue 1, p364
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Acute clamping of the vascular pedicle of a kidney decreases the sodium reabsorption in the proximal tubule of the contralateral kidney. Under these conditions, no change in the intrarenal blood flow could he demonstrated either by krypton85 disappearance curves, autoradiograms, or silicone rubber vascular casts. On the other hand, when the renal mass was chronically reduced using Bricker's model, and 70 to 80% of the branches of the renal artery were ligated (stage II), the blood flow rates of the first anti second components ol the experimental remnant kidney (626 ± 16 and 133 ± 8 ml/min/100 g) were comparable to those of the control kidney (679 ± 41 and 127 ± 5 ml/min/100 g). However, the initial distribution of the radioactivity was significantly decreased in the first compartment of the experimental remnant kidney in comparison to that of the control kidney (81 ± 1.5% vs. 63 ± 7%) These changes were reversed for the second component (14 ± 4% vs. 27 ± 5%). The autoradiograrns and silicone rubber vascular casts confirm these observations. In stage II dogs that had not been used for experimental procedure, the normal kidney was removed (stage III). An impressive vasodilatation was observed in all regions of the remnant kidney. along with the marked diminution of the proximal and distal sodium reabsorption. These hemodynamic changes cannot be explained by changes in blond pressure nor by the uremia per se since dogs which were unincphrectomized only presented the same vascular changes. Other mechanisms responsible for the hemodynamic changes observed should therefore be considered.
ACCESSION #
18287725

 

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