TITLE

Importance of ultrafilterable plasma factors in maintaining tubular reabsorption

AUTHOR(S)
Bartoli, Ettore; Earley, Laurence E.
PUB. DATE
January 1973
SOURCE
Kidney International;Jan1973, Vol. 3 Issue 1, p142
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The recollection technique was used to measure reabsorptive rates in rat proximal tubules during in situ microperfusion with an artificial perfusate or an ultrafiltrate of rat plasma. During one minute of microperfusion reabsorptive rates were no different with the two solutions, Reabsorption decreased 34% when remeasured at ten minutes in the same tubule during continuous perfusion with the artificial solution. No decrease occurred when paired measurements were made at one and ten minutes during continuous perfusion with an ultrafiltrate of plasma. These results suggest that some constituents of plasma other than major electrolytes and glucose are necessary within the lumen to maintain a constant rate of proximal tubular reabsorption. The effect of perfusion rate on the rate of reabsorption was reinvestigated by the recollection technique using plasma ultrafiltrate as the perfusate. Overall, a two-fold change in perfusion rate did not change reabsorptive rate. When only long tubule segments were analyzed (increasing the accuracy of measuring changes) a relationship between perfusion rate and reabsorptive rate was apparent. The change in reabsorptive rate averaged 40% of the change in perfusion rate. The results of these studies indicate that unidentified constituents of normal glomerular filtrate as well as intraluminal flow rate can influence proximal tubular reabsorption.
ACCESSION #
18287613

 

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