Mechanisms of hypocomplementemia in glomerulonephritis

West, Clark D.; Ruley, Edward J.; Forristal, Judith; Davis, Neil C.
January 1973
Kidney International;Jan1973, Vol. 3 Issue 1, p116
Academic Journal
The article presents information on the mechanism of hypocomplementemia in glomerulonephritis. Complement can be demonstrated in the glomeruli in nephritides which are not associated with a reduction in serum complement. Complement profiles have shown that in some hypocomplementemic nephritides, certain components are in normal concentration while in others, all components tend to be low. In hypocomplementemic patients with membrano-proliferative nephritis, a factor has been found in the serum which appears to be responsible for the hypocomplementemia.


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