Micropuncture study in rats with experimental glomerulonephritis

Rocha, Antonino; Marcondes, Marcello; Malnic, Gerhard
January 1973
Kidney International;Jan1973, Vol. 3 Issue 1, p14
Academic Journal
Experiments were carried out to study the function of individual nephrons in rats with membranous glomerulonephritis produced by the intravenous administration of rabbit anti-rat- kidney serum. The nephritic animals developed massive proteinria, hypoalburninemia, hypercholesterolemia, edema and ascites. Considerable heterogeneity of nephron function was observed in nephritic rats. Some proximal nephrons showed normal glomerulotubular balance while others had low glomerular filtration rates (GFR) associated with high tubular fluid/plasma inulin ratios. Mean single nephron GFR and total GFR were decreased in nephritic rats while proximal half-time of reabsorption and transit time were increased. Free flow pressure in proximal tubules was within normal limits while glomerular filtration pressure was significantly reduced. In average terms, the fractional reabsorption of sodium along the diseased nephron was not different from controls: however, due to the reduced filtered load, less sodium was excreted per kg rat. The nephritic rat was also not able to concentrate the urine to the extent of the normal.


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