TITLE

The more closed the bypass system the better: a pilot study on the effects of reduction of cardiotomy suction and passive venting on hemostatic activation during on-pump coronary artery bypass grafting

AUTHOR(S)
Koster, Andreas; Böttcher, Wolfgang; Merkel, Frank; Hetzer, Roland; Kuppe, Hermann
PUB. DATE
September 2005
SOURCE
Perfusion;Sep2005, Vol. 20 Issue 5, p285
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Cardiac surgery with cardiopulmonary bypass (CPB) leads to a powerful activation of the hemostatic system. We assessed to what extent this activation can be attenuated by comparing three different perfusion regimens for on-pump coronary artery bypass grafting (CABG): 1) use of a closed CPB system with aspiration of blood from the operation field via the cardiotomy suction line and active venting of the heart via a roller pump; 2) use of a closed CPB system avoiding aspiration of blood from the operation field via the cardiotomy suction line, but with active venting of the heart; and 3) use of a closed system, avoidance of aspiration of blood from the operation field via the cardiotomy suction line and with passive venting of the heart into the collapsible venous reservoir. Our data show that avoidance of aspiration of blood via the cardiotomy suction line significantly reduces hemostatic activation during on-pump CABG. However, further attenuation of hemostatic activation can be achieved by further closing the system and minimizing the blood/air interface by passive venting of the heart.
ACCESSION #
18281898

 

Related Articles

  • Will off-pump coronary artery surgery replace conventional coronary artery surgery? Raja, Shahzad G.; Dreyfus, Gilles D. // Journal of the Royal Society of Medicine;Jun2004, Vol. 97 Issue 6, p275 

    The article provides information on off-pump coronary artery bypass (OPCAB) over the conventional coronary artery bypass grafting in treating coronary artery diseases. OPCAB is a surgery on a beating heart without the support of cardiopulmonary bypass. The disadvantages and advantages of...

  • Off-pump coronary artery bypass grafting: the myth, the logic and the science Ngaage, Dumbor L. // European Journal of Cardio-Thoracic Surgery;Oct2003, Vol. 24 Issue 4, p557 

    Coronary artery bypass grafting is a highly investigated surgical procedure and yet continues to attract rigorous research aimed at reducing observed and potential morbidity and mortality. Improvements in perioperative care, surgical technique and methods of attenuating the untoward effects of...

  • Effect of off-pump coronary artery bypass surgery on clinical, angiographic, neurocognitive, and quality of life outcomes: randomised controlled trial. Al-Ruzzeh, Sharif; George, Shane; Bustami, Mahmoud; Wray, Jo; Ilsley, Charles; Athanasiou, Thanos; Amrani, Mohamed // BMJ: British Medical Journal (International Edition);6/10/2006, Vol. 332 Issue 7554, p1365 

    Objective To compare the clinical, angiographic, neurocognitive, and quality of life outcomes of off-pump coronary artery bypass surgery with conventional coronary artery bypass grafting surgery using cardiopulmonary bypass. Design Randomised controlled clinical trial. Setting Tertiary...

  • Microemboli and Cerebral Impairment During Cardiac Surgery. Pugsley, W.; Klinger, L.; Paschalis, C.; Aspey, B.; Newman, S.; Harrison, M.; Treasure, T. // Vascular Surgery;Jan/Feb1990, Vol. 24 Issue 1, p34 

    Arterial microemboli, which may be reduced by arterial line filtration, have been proposed as a factor contributing to cardiopulmonary bypass (CPB)-related cerebral dysfunction. The authors report on a study investigating the effects of arterial line filtration on the incidence of microemboli...

  • A new approach to the assessment of lumen visibility of coronary artery stent at various heart rates using 64-slice MDCT. Groen, J. M.; Greuter, M. J. W.; Ooijen, P. M. A.; Oudkerk, M. // European Radiology;Jul2007, Vol. 17 Issue 7, p1879 

    Coronary artery stent lumen visibility was assessed as a function of cardiac movement and temporal resolution with an automated objective method using an anthropomorphic moving heart phantom. Nine different coronary stents filled with contrast fluid and surrounded by fat were scanned using...

  • Total arterial revascularisation: effect of avoiding cardiopulmonary bypass on in-hospital mortality and morbidity in a propensity-matched cohort Pandey, Ragini; Grayson, Antony D.; Pullan, D. Mark; Fabri, Brian M.; Dihmis, Walid C. // European Journal of Cardio-Thoracic Surgery;Jan2005, Vol. 27 Issue 1, p94 

    Abstract: Objective: The combination of total arterial revascularisation and avoidance of cardiopulmonary bypass may provide additional benefits to patients receiving complete arterial grafting with cardiopulmonary bypass. We performed a propensity-matched cohort study of complete arterial...

  • Arterio-venous gradients of free energy change for assessment of systemic and splanchnic perfusion in cardiac surgery patients. Braun, Jan-Peter; Jakob, Stephan M.; Volk, Thomas; Doepfmer, Ulrich R.; Moshirzadeh, Maryam; Stegmann, Shirin; Dohmen, Pascal M.; Spies, Claudia // Perfusion;Nov2006, Vol. 21 Issue 6, p353 

    Objective: Adequacy of organ perfusion depends on sufficient oxygen supply in relation to the metabolic needs. The aim of this study was to evaluate the relationship between gradients of free energy change, and the more commonly used parameter for the evaluation of the adequacy of organ...

  • Recent advances in paediatric cardiopulmonary bypass. Elliott, M.J. // Perfusion;1999, Vol. 14 Issue 4, p237 

    Focuses on the advances in cardiopulmonary bypass (CPB) procedure among pediatric patients. Pattern of surgical repair for coronary heart disease; Information on conventional haemodilutional CPB; Neurological consequences of CPB.

  • Evaluation of an alternative S100b assay for use in cardiac surgery: relationship with microemboli and neuropsychological outcome. Whitaker, D. C.; Green, A. J. E.; Stygall, J.; Harrison, M. J. G.; Newman, S. P. // Perfusion;Jul2007, Vol. 22 Issue 4, p267 

    Introduction. The aim of the study was to investigate the relationship between S100b release, neuropsychological outcome and cerebral microemboli. Peri-operative assay of the astroglial cell protein S100b has been used as a marker of cerebral damage after cardiac surgery but potential assay...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics