TITLE

Daptomycin-Resistant Enterococcus faecium in a Patient With Acute Myeloid Leukemia

AUTHOR(S)
Long, Jennifer K.; Choueiri, Tono K.; Hall, Geraldine S.; Avery, Robin K.; Sekeres, Mikkael A.
PUB. DATE
September 2005
SOURCE
Mayo Clinic Proceedings;Sep2005, Vol. 80 Issue 9, p1215
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Daptomycin is a lipopeptide antimicrobial used for the treatment of aerobic gram-positive skin and soft tissue infections. We describe a patient with acute myeloid leukemia whose febrile neutropenia was treated with daptomycin and who later developed daptomycin-resistant Enterococcus faecium infection. Defervescence and negative blood cultures ensued after treatment with linezolid. Guidelines for testing daptomycin susceptibilities of enterococci include breakpoints only for vancomycin-susceptible Enterococcus faecalis, making interpretation of minimum inhibitory concentrations for common clinical Infections difficult. No enterococcal cross-resistance has been reported among daptomycin, linezolid, or quinupristin-dalfopristin, and these agents may be viable alternatives.
ACCESSION #
18184330

 

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics