TITLE

INFECTION, INFLAMMATION, AND GASTROINTESTINAL CANCER

AUTHOR(S)
Boland, C. R.; Luciani, M. G.; Gasche, C.; Goel, A.
PUB. DATE
September 2005
SOURCE
Gut;Sep2005, Vol. 54 Issue 9, p1321
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The article focus on two novel mechanisms involved in the development of colorectal cancer (CRC). Firstly, a virus carried by most healthy individuals has been implicated as a possible cause for chromosomal instability, the process that leads to aneuploidy. Chromosomal aberrations play a major role in the development and progression of multistep carcinogenesis, such as occurs in CRC. Secondly, it is abundantly clear that inflammation is carcinogenic, and furthermore, endogenous processes that can modify the ability of the host to cope with inflammation appear to modify the risk of cancer to the host.
ACCESSION #
18143432

 

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