Boland, C. R.; Luciani, M. G.; Gasche, C.; Goel, A.
September 2005
Gut;Sep2005, Vol. 54 Issue 9, p1321
Academic Journal
The article focus on two novel mechanisms involved in the development of colorectal cancer (CRC). Firstly, a virus carried by most healthy individuals has been implicated as a possible cause for chromosomal instability, the process that leads to aneuploidy. Chromosomal aberrations play a major role in the development and progression of multistep carcinogenesis, such as occurs in CRC. Secondly, it is abundantly clear that inflammation is carcinogenic, and furthermore, endogenous processes that can modify the ability of the host to cope with inflammation appear to modify the risk of cancer to the host.


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