Anti-Saccharomyces cerevisiae antibodies in twins with inflammatory bowel disease

Halfvarson, J.; Standaert-Vitse, A.; Järnerot, G.; Sendid, B.; Jouoult, L.; Bodin, L.; Duhamel, A.; Colombel, J. F.; Tysk, C.; Poulain, D.
September 2005
Gut;Sep2005, Vol. 54 Issue 9, p1237
Academic Journal
Background and aims: An increased occurrence of anti-Saccharomyces cerevisiae antibodies (ASCA) is reported in unaffected members of families with Crohn's disease. Whether ASCA is a familial trait due to genetic factors or is caused by exposure to environmental factors is unknown. To assess the genetic influence of ASCA we studied its occurrence in a twin population. Patients and methods: ASCA were analysed in 98 twin pairs with inflammatory bowel disease and were related to clinical phenotype and CARD 15/NOD2 genotype. Results: ASCA were more common in Crohn's disease than in ulcerative colitis (40/70(57%) twins v 5/43 (12%) twins). Associations with ileal Crohn's disease, stricturing/penetrating behaviour, and young age, but not CARD15/NOD2 were confirmed. ASCA were found in 1/20 (5%) healthy siblings in discordant monozygotic pairs with Crohn's disease compared with 7/27(26%) in discordant dizygotic pairs. Using the intraclass correlation coefficient (ICC), no agreement in ASCA titres was observed in discordant twin pairs with Crohn's disease, in monozygotic (ICC = -0.02) or dizygotic (ICC = -0.26) pairs. In contrast, strong agreement was seen within concordant monozygotic twin pairs with Crohn's disease (ICC = 0.76). Conclusions: These findings question the concept of ASCA as a marker of genetic susceptibility for Crohn's disease. The agreement in ASCA titres within concordant monozygotic twin pairs with Crohn's disease, suggests that the level of increase is genetically determined. We propose that ASCA are a marker of a response to an environmental antigen and that a specific gene(s) other than CARD15/NOD2 determines the level of response and perhaps also specific phenolypic characteristics.


Related Articles

  • The role of red cell distribution width as a marker in inflammatory bowel disease. ARHAN, Mehmet; ÖNAL, İbrahim Koral; TAŞ, Adnan; KURT, Mevlüt; KALKAN, İsmail Hakkı; ÖZİN, Yasemin; TUNÇ, Bilge; ÜLKER, Aysel // Turkish Journal of Medical Sciences;Apr2011, Vol. 41 Issue 2, p227 

    No abstract available.

  • Familial Expression of Anti-Saccharomyces cerevisiae Mannan Antibodies in Crohn's Disease and Ulcerative Colitis: A GISC Study. Annese, V.; Anmdreoli, A.; Andriulli, A.; D'Inca, R.; Giochetti, P.; Latiano, A.; Lombardi, G.; Piepoli, A.; Poulain, D.; Sendid, B.; Colombardi, J. F. // American Journal of Gastroenterology;Aug2001, Vol. 96 Issue 8, p2407 

    OBJECTIVES: Recent studies in familial Crohn's disease (CD) have suggested that anti-Saccharomyces cerevisiae mannan antibodies (ASCAs) may represent a new specific marker of genetic susceptibility. In this study we aimed to assess the importance of ASCAs by comparing their presence in...

  • Diagnostic Value of Anti-Saccharomyces cerevisiae and Antineutrophil Cytoplasmic Autoantibodies in Inflammatory Bowel Disease. Peeters, Marc; Joossens, Sofie; Vermeire, Severine; Vlietinck, Robert; Bossuyt, Xavier; Rutgeerts, Paul // American Journal of Gastroenterology;Mar2001, Vol. 96 Issue 3, p730 

    OBJECTIVES: Correct diagnosis of inflammatory bowel disease (IBD), especially the differentiation between Crohn's disease (CD) and ulcerative colitis (UC), is highly important toward treatment and prognosis. Serological markers are noninvasive diagnostic tools that could be of value in...

  • Characterization of Changes in Serum Anti-Glycan Antibodies in Crohn's Disease - a Longitudinal Analysis. Rieder, Florian; Lopez, Rocio; Franke, Andre; Wolf, Alexandra; Schleder, Stephan; Dirmeier, Andrea; Schirbel, Anja; Rosenstiel, Philip; Dotan, Nir; Schreiber, Stefan; Rogler, Gerhard; Klebl, Frank // PLoS ONE;2011, Vol. 6 Issue 5, p1 

    Introduction: Anti-glycan antibodies are a promising tool for differential diagnosis and disease stratification of patients with Crohn's disease (CD). We longitudinally assessed level and status changes of anti-glycan antibodies over time in individual CD patients as well as determinants of this...

  • Serological markers of inflammatory bowel disease. Kuna, Andrea Tešija // Biochemia Medica;2013, Vol. 23 Issue 1, p28 

    Inflammatory bowel disease (IBD) is a heterogeneous group of chronic inflammatory disorders of the gastrointestinal tract with two main distinguishable entities, Crohn's disease (CO) and ulcerative colitis (UC). IBD-undassified (IBD-U) is a diagnosis that covers the "grey" zone of diagnostic...

  • Inflammatory Bowel Disease: Autoimmune or Immune-mediated Pathogenesis? Zhonghui Wen; Fiocchi, Claudio // Clinical & Developmental Immunology;Sep-Dec2004, Vol. 11 Issue 3/4, p195 

    The pathogenesis of Crohn's disease (CD) and ulcerative colitis (UC), the two main forms of inflammatory bowel disease (IBD), is still unclear, but both autoimmune and immune-mediated phenomena are involved. Autoimmune phenomena include the presence of serum and mucosal autoantibodies against...

  • Diagnostic Role and Clinical Association of ASCA and ANCA in Brazilian Patients with Inflammatory Bowel Disease. Nisihara, Renato; Carvalho, Wilson; Rosa Utiyama, Shirley; Amarante, Heda; Baptista, Márcia // Digestive Diseases & Sciences;Aug2010, Vol. 55 Issue 8, p2309 

    Anti- Saccharomyces cerevisae antibody (ASCA) and perinuclear anti-neutrophil cytoplasmatic antibody (pANCA) remain the most well-established markers in inflammatory bowel disease (IBD), and both may be associated with disease phenotype. To determine the utility of ASCA and pANCA as markers in a...

  • New serological biomarkers of inflammatory bowel disease. Xuhang Li; Conklin, Laurie; Alex, Philip; Mizoguchi, Emiko // World Journal of Gastroenterology;9/7/2008, Vol. 14 Issue 33, p5115 

    Serological biomarkers in inflammatory bowel disease (IBD) are a rapidly expanding list of non-invasive tests for objective assessments of disease activity, early diagnosis, prognosis evaluation and surveillance. This review summarizes both old and new biomarkers in IBD, but focuses on the...

  • Novel Anti-Glycan Antibodies Related to Inflammatory Bowel Disease Diagnosis and Phenotype. Seow, Cynthia H.; Stempak, Joanne M.; Wei Xu; Hui Lan; Griffiths, Anne M.; Greenberg, Gordon R.; Steinhart, A. Hillary; Dotan, Nir; Silverberg, Mark S. // American Journal of Gastroenterology;Jun2009, Vol. 104 Issue 6, p1426 

    OBJECTIVES:We sought to evaluate whether two novel immunoglobulin A (IgA) cell wall polysaccharide antibodies, anti-laminarin (anti-L) and anti-chitin (anti-C), aid in the diagnosis and phenotype differentiation of Crohn's disease (CD) and ulcerative colitis (UC).METHODS:A cohort of 818...


Read the Article


Sign out of this library

Other Topics