ASCA: genetic marker, predictor of disease, or marker of a response to an environmental antigen?

Seibold, F.
September 2005
Gut;Sep2005, Vol. 54 Issue 9, p1212
Academic Journal
Presents information on anti-saccharomyces cerevisiae antibodies (ASCA). Use of ASCA as a marker of an immune response to an environmental antigen; Role of ASCA in inflammatory bowl disease (IBD); Generation of ASCA and primary sclerosing cholangitis in the human body; Prevalence of ASCA in patients with IBD.


Related Articles

  • The role of red cell distribution width as a marker in inflammatory bowel disease. ARHAN, Mehmet; ÖNAL, İbrahim Koral; TAŞ, Adnan; KURT, Mevlüt; KALKAN, İsmail Hakkı; ÖZİN, Yasemin; TUNÇ, Bilge; ÜLKER, Aysel // Turkish Journal of Medical Sciences;Apr2011, Vol. 41 Issue 2, p227 

    No abstract available.

  • Anti-Saccharomyces cerevisiae antibodies in twins with inflammatory bowel disease. Halfvarson, J.; Standaert-Vitse, A.; Järnerot, G.; Sendid, B.; Jouoult, L.; Bodin, L.; Duhamel, A.; Colombel, J. F.; Tysk, C.; Poulain, D. // Gut;Sep2005, Vol. 54 Issue 9, p1237 

    Background and aims: An increased occurrence of anti-Saccharomyces cerevisiae antibodies (ASCA) is reported in unaffected members of families with Crohn's disease. Whether ASCA is a familial trait due to genetic factors or is caused by exposure to environmental factors is unknown. To assess the...

  • Anti-Saccharomyces cerevisiae Mannan Antibodies and Antineutrophil Cytoplasmic Autoantibodies in Greek Patients With Inflammatory Bowel Disease. Koutroubakis, Ioannis E.; Petinaki, Efthymia; Mouzas, Ioannis A.; Vlachonikolis, Ioannis G.; Anagnostopoulou, Evangelia; Castanas, Elias; Maniatis, Antonios N.; Kouroumalis, Elias A. // American Journal of Gastroenterology;Feb2001, Vol. 96 Issue 2, p449 

    OBJECTIVES: The combined measurement of perinuclear antineutrophil cytoplasmic autoantibodies (pANCA) and anti-Saccharomyces cerevisiae mannan antibodies (ASCA) has recently been suggested as a valuable diagnostic approach in inflammatory bowel disease (IBD). The aim of this study was...

  • Anti-Saccharomyces cerevisiae and antineutrophil cytoplasmic antibodies as predictors of inflammatory bowel disease. Israeli, E.; Grotto, I.; Gilburd, B.; Balicer, R. D.; Goldin, E.; Wiik, A.; Shoenfeld, Y. // Gut;Sep2005, Vol. 54 Issue 9, p1232 

    Background and aims: Several antibodies have been reported in the sera of patients with Crohn's disease (CD) and ulcerative colitis (UC). The most commonly described are anti-Saccharomyces cerevisiae mannan antibodies (ASCA) in CD and perinuclear antineutrophil cytoplasm antibodies (pANCA) in...

  • New serological biomarkers of inflammatory bowel disease. Xuhang Li; Conklin, Laurie; Alex, Philip; Mizoguchi, Emiko // World Journal of Gastroenterology;9/7/2008, Vol. 14 Issue 33, p5115 

    Serological biomarkers in inflammatory bowel disease (IBD) are a rapidly expanding list of non-invasive tests for objective assessments of disease activity, early diagnosis, prognosis evaluation and surveillance. This review summarizes both old and new biomarkers in IBD, but focuses on the...

  • IgG Oligosaccharide Alterations Are a Novel Diagnostic Marker for Disease Activity and the Clinical Course of Inflammatory Bowel Disease. Shinzaki, Shinichiro; Iijima, Hideki; Nakagawa, Takatoshi; Egawa, Satoshi; Nakajima, Sachiko; Ishii, Shuji; Irie, Takanobu; Kakiuchi, Yoshimi; Nishida, Tsutomu; Yasumaru, Masakazu; Kanto, Tatsuya; Tsujii, Masahiko; Tsuji, Shingo; Mizushima, Tsunekazu; Yoshihara, Harumasa; Kondo, Akihiro; Miyoshi, Eiji; Hayashi, Norio // American Journal of Gastroenterology;May2008, Vol. 103 Issue 5, p1173 

    BACKGROUND AND AIMS: Patients with inflammatory bowel disease (IBD) share several immunologic similarities with rheumatoid arthritis (RA). Patients with RA have significantly increased levels of serum agalactosyl immunoglobulin G (IgG). Our aim was to investigate the clinical significance of...

  • Variants of CARD15 are Associated with an Aggressive Clinical Course of Crohn's Disease–An IG-IBD Study. Annese, Vito; Lombardi, Giovanni; Perri, Francesco; D'Inc, Renata; Ardizzone, Sandro; Riegler, Gabriele; Giaccari, Stelio; Vecchi, Maurizio; Castiglione, Fabiana; Gionchetti, Paolo; Cocchiara, Elena; Vigneri, Sergio; Latiano, Anna; Palmieri, Orazio; Andriulli, Angelo // American Journal of Gastroenterology;Jan2005, Vol. 100 Issue 1, p84 

    BACKGROUND: Three major variants of the CARD15 gene confer susceptibility to Crohn's disease (CD). Whether or not these variants correlate with specific clinical features of the disease is under evaluation.AIM: We investigated the possible association of CARD15 variants with specific clinical...

  • Familial Expression of Anti-Saccharomyces cerevisiae Mannan Antibodies in Crohn's Disease and Ulcerative Colitis: A GISC Study. Annese, V.; Anmdreoli, A.; Andriulli, A.; D'Inca, R.; Giochetti, P.; Latiano, A.; Lombardi, G.; Piepoli, A.; Poulain, D.; Sendid, B.; Colombardi, J. F. // American Journal of Gastroenterology;Aug2001, Vol. 96 Issue 8, p2407 

    OBJECTIVES: Recent studies in familial Crohn's disease (CD) have suggested that anti-Saccharomyces cerevisiae mannan antibodies (ASCAs) may represent a new specific marker of genetic susceptibility. In this study we aimed to assess the importance of ASCAs by comparing their presence in...

  • Higher Titers of Anti-Saccharomyces Cerevisiae Antibodies IgA and IgG are Associated with More Aggressive Phenotypes in Romanian Patients with Crohn's Disease. Gologan, Serban; Iacob, Razvan; Preda, Carmen; Vadan, Roxana; Cotruta, Bogdan; Catuneanu, Ana-Maria; Iacob, Speranta; Constantinescu, Ileana; Gheorghe, Liana; Iobagiu, Silviu; Gheorghe, Cristian; Diculescu, Mircea // Journal of Gastrointestinal & Liver Diseases;Mar2012, Vol. 21 Issue 1, p39 

    Background & Aims. Serological markers have been widely used for diagnostic purposes and disease stratification in inflammatory bowel diseases (IBD). The aim of this study was to investigate the seroprevalence and the correlations of anti-Saccharomyces cerevisiae antibodies (ASCA) titers with...


Read the Article


Sign out of this library

Other Topics