Colorectal cancer prognosis: is it all mutation, mutation, mutation?

Hassan, A. B.; Paraskeva, C.
September 2005
Gut;Sep2005, Vol. 54 Issue 9, p1209
Academic Journal
The article presents information on colorectal cancer prognosis. Mutational analysis and genetic models have identified the key pathways critical for initiation and progression of colorectal cancer. Deregulation of the Wnt signaling pathway, by either loss of function or gain of function mutations of adenomatous polyposis coli and beta-catenin, respectively, in both hereditary and sporadic colorectal adenoma, establish the principal initiation pathway. The discriminating power and clinical utility of these mutations have proven to be less impressive, even though this pathway remains to be a critical therapeutic target.


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