Susceptibility trends of pseudomonas species from corneal ulcers

Smitha, S.; Lalitha, P.; Prajna, V. N.; Srinivasan, M.
July 2005
Indian Journal of Medical Microbiology;Jul2005, Vol. 23 Issue 3, p168
Academic Journal
journal article
Purpose: To assess the changing trends in the antibiotic susceptibility of Pseudomonas spp . isolated from bacterial keratitis over a nine year period with special emphasis on fluoroquinolone susceptibilities.Methods: All corneal scraping cultures positive for Pseudomonas spp. (n=585) isolated from patients with bacterial keratitis at the Aravind Eye Hospital, Madurai from 1995-2003 were evaluated. Cultures were performed in liquid and solid media and susceptibility testing was done against amikacin, gentamicin, tobramycin, ciprofloxacin and ofloxacin by Kirby-Bauer disc diffusion method.Results: The susceptibility of Pseudomonas spp. was over 90% from 1995-1998 to ciprofloxacin which decreased to 83% from 1999-2003. The total number of isolates resistant to ciprofloxacin was 51 (9.4%). No statistically significant increase in the number of isolates resistant to ciprofloxacin was noted. Ofloxacin showed 54% susceptibility from 1995-1998 but increased to 64% from 1999-2003. Analysis of in vitro activity of amikacin reveals that there was 43% sensitivity from 1995-1998 but later it increased to 76% from 1999-2003. In case of gentamicin, the sensitivity decreased marginally from 80% to 70% through the years. Tobramycin showed 45% sensitivity from 1995-1998 but increased to 75% from 1999-2003.Conclusions: The fluoroquinolones remain a good choice in the treatment of ocular infections, with high susceptibility of Pseudomonas spp. Among the aminoglycosides, gentamicin was found to be highly effective against Pseudomonas corneal ulcers when compared to amikacin and tobramycin. The results show a need for continuous monitoring of bacterial resistance trends.


Related Articles

  • Pseudomoans among most virulent of corneal pathogens. Guttman, Cheryl // Ophthalmology Times;3/15/2009, Vol. 34 Issue 6, p47 

    The article discusses the diagnostic and treatment options for Pseudomonas keratitis. Therapeutic options cited include fluoroquinolones, antibiotics and the combination of monotherapy and a second-generation fluoroquinolone. It also addressed the impact of the emergence of bacterial infections,...

  • Susceptibility Testing of P. aeruginosa Clinical Isolates to Levofloxacin, Moxifloxacin and Gatifloxacin. Shovlin, Joseph P.; DeAngelis, Therese // Review of Optometry;5/15/2004 Supplement, p30 

    Evaluates the antibiotics susceptibility of random clinical isolates of Pseudomonas aeruginosa to levofloxacin, moxifloxacin and gatifloxacin, potential agents for the treatment of pseudomonas keratitis. Minimum inhibitory concentration of antibiotics; Susceptibility to the post-second...

  • Factors Influencing Fluoroquinolone Resistance. Sahm, Daniel F.; Thornsberry, Clyde; Jones, Mark E.; Karlowsky, James A. // Emerging Infectious Diseases;Dec2003, Vol. 9 Issue 12, p1651 

    Focuses on factors that have an influence on the efficacy of fluoroquinolones against Pseudomonas aeruginosa. Comparison of the efficacy of fluoroquinolones with ciprofloxacin; Side effects of targeted fluoroquinolone therapy; Fluoroquinolone resistance in enteric bacteria.

  • A practical guide to the fluoroquinolones. D'Epiro, Peter; Cheng, Cynthia // Patient Care;1/15/2002, Vol. 36 Issue 1, p20 

    Presents an approach to the appropriate use of quinolones. Description of the anti-bacterial action of fluoroquinolones; Classification; Adverse effects.

  • Fluoroquinolone misuse in ER creates concern. Pfeiffer, Naomi // Dermatology Times;Jul2001, Vol. 22 Issue 7, p1 

    Cites research findings on the misuse of fluoroquinolone antibiotics in emergency rooms. Inappropriate dispensing of the antibiotic to patients; Impact of antibiotic misuse on the emergence of fluoroquinolone resistance; Need for a more vigorous campaign to educate physicians.

  • Fluoroquinolones in Paediatrics. Gendrel, D.; Moulin, F. // Pediatric Drugs;2001, Vol. 3 Issue 5, p365 

    The fluoroquinolones are an important group of antibiotics, which are widely used in adult patients because of their high penetration in tissues and bactericidal activity. However, they are not licensed for paediatric use (except the limited indication of Pseudomonas infection in cystic...

  • OVERVIEW OF THE FLUOROQUINOLONES focus on moxifloxacin. Andriole, Vincent T. // Managed Healthcare Executive;Jun2002 Supplement 1, Vol. 12 Issue 6, p13 

    Investigates the properties and clinical capabilities of fluoroquinolones or quinolones antibacterial agents. Historical background; Differentiation between the generations of quinolones; Details on structure and properties of the fluoroquinolones antibiotic moxifloxacin.

  • Clinical Q & A. Nathan, Joseph P. // Drug Topics;2/1/99, Vol. 143 Issue 3, p35 

    Provides information on the differences of fluoroquinolone antibiotics. Characteristics of some quinolones; Significance of close monitoring of the international normalized ratio; Advantages and disadvantages of different type of fluoroquinolone.

  • New Classification and Update on the Quinolone Antibiotics. King, Dana E.; Malone, Robb; Lilley, Sandra H. // American Family Physician;5/1/2000, Vol. 61 Issue 9, p2741 

    Presents an update on quinolone antibiotics. Overview of fluoroquinolones; Classification of quinolones; Cost of fluoroquinolone therapy.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics