Immunotherapy for West Nile virus infection
- A Therapeutic Antibody against West Nile Virus Neutralizes Infection by Blocking Fusion within Endosomes. Thompson, Bruce S.; Moesker, Bastiaan; Smit, Jolanda M.; Wilschut, Jan; Diamond, Michael S.; Fremont, Daved H. // PLoS Pathogens;May2009, Vol. 5 Issue 5, p1
Defining the precise cellular mechanisms of neutralization by potently inhibitory antibodies is important for understanding how the immune system successfully limits viral infections. We recently described a potently inhibitory monoclonal antibody (MAb E16) against the envelope (E) protein of...
- Development of a humanized monoclonal antibody with therapeutic potential against West Nile virus. Oliphant, Theodore; Engle, Michael; Nybakken, Grant E.; Doane, Chris; Johnson, Syd; Ling Huang; Gorlatov, Sergey; Mehlhop, Erin; Marri, Anantha; Kyung Min Chung; Ebel, Gregory D.; Kramer, Laura D.; Fremont, Daved H.; Diamond, Michael S. // Nature Medicine;May2005, Vol. 11 Issue 5, p522
Neutralization of West Nile virus (WNV) in vivo correlates with the development of an antibody response against the viral envelope (E) protein. Using random mutagenesis and yeast surface display, we defined individual contact residues of 14 newly generated monoclonal antibodies against domain...
- West Nile virus--Canada's index case. Epstein, Norman L. // CJEM: Canadian Journal of Emergency Medicine;Mar2003, Vol. 5 Issue 2, p101
Presents the case of a 70-year-old male infected with the West Nile virus in Canada in mid-August 2002. Symptoms and diagnosis; Treatment options; Implications on emergency medicine.
- This Summer, What You Should Know About West Nile Virus. Crane, John K. // Cortlandt Forum;6/25/2003, Vol. 16 Issue 6, p35
Provides information on West Nile virus (WNV). Spread in the U.S.; Number of states with WNV cases; Species susceptible to the virus; Symptoms; Confirmation of infection; Treatment options available.
- West Nile Virus Activity -- United States, September 8-14, 2004. // MMWR: Morbidity & Mortality Weekly Report;9/17/2004, Vol. 53 Issue 36, p850
This article focuses a report related to West Nile virus activity in the United States, during September 8-14, 2004. During this period, a total of 195 cases of human West Nile virus (WNV) illness were reported from 26 states of the country. During 2004, a total of 39 states have reported 1,386...
- No West Nile here. Cano, Angele // Hub (Hay River, NT);9/5/2012, Vol. 40 Issue 28, p12
The article reports on the 19 cases of West Nile virus in Canada in 2012 and offers information on its symptoms.
- What FPs need to know about West Nile virus disease. Henley, Eric // Journal of Family Practice;Sep2003, Vol. 52 Issue 9, p711
This article describes the transmission, diagnosis, treatment and prevention of West Nile virus infection. Most cases of infections result from mosquito bites. But other mechanisms include needle sticks in lab workers and possibly breast milk. The infection can be asymptomatic, mild or severe....
- Monoclonal antibodies to Kunjin and Kokobera viruses. Hall, Roy A.; Burgess, Graham W.; Kay, Brian H.; Clancy, Paula // Immunology & Cell Biology;Feb1991, Vol. 69 Issue 1, p47
Five monoclonal antibodies (MoAb) were produced to the envelope (E) protein of Kunjin (KUN) virus. Three of these were specific for the KUN/West Nile complex, and two reacted with epitopes that were common to the flavivirus family. These MoAb defined at least four distinct epitopes on the E...
- Death in the sun. Ananthaswamy, Anil // New Scientist;7/26/2003, Vol. 179 Issue 2405, p12
Warmer climates, vulnerable populations, and unique bird and animal life mean that West Nile virus' impact on Latin America could be devastating. This virus is spread by mosquitoes and birds, which could make Latin American countries ideal breeding grounds, because of their warmer climate, large...