Study of clinical profile and antibiotic response in typhoid fever

Chowta, M. N.; Chowta, N. K.
April 2005
Indian Journal of Medical Microbiology;Apr2005, Vol. 23 Issue 2, p125
Academic Journal
journal article
The objective of the present study is to evaluate the clinical profile and pattern of various drugs used in the treatment of typhoid fever. A retrospective analysis of adult patients suffering from typhoid fever was done at Kasturba Medical College hospital, Attavar during the year 1999-2001. Diagnosis of patients was based on clinical features, widal test and blood culture. The sensitivity pattern of isolates from blood culture was recorded. The mode of presentation, clinical course, treatment history, laboratory investigations reports, antibiotic administered, response to therapy and the complications were recorded. Total number of 44 cases of typhoid fever were studied. Out of these 21(47.7%) were males and 23(52.3%) were females. Average age of presentation was 23.9 years. Average duration of hospital stay was 10.8 days. Fever was present in all patients. Resistance of S. typhi to amoxicillin, chloramphenicol, ampicillin and co-trimoxazole were significantly high. Ciprofloxacin also showed resistance in 18.1% of cases. Sensitivity to cephalosporin was 100% in our study. Ciprofloxacin was the most commonly used antibiotic in our study (23 patients). Chloramphenicol alone was used in 2 patients and in 3 patients it was given after 6 days of ciprofloxacin treatment. Third generation cephalosporins (ceftriaxone) alone were used in 16 patients. Indiscriminate use of drugs in typhoid fever should be discouraged. Appropriate antibiotic as indicated by sensitivity tests should be employed to prevent the development of resistant strains of S. typhi.


Related Articles

  • Further experience with amoxycillin in typhoid fever in children. Scragg, J.N. // British Medical Journal;10/30/1976, Vol. 2 Issue 6043, p1031 

    Compares the therapuetic effectiveness of amoxycillin and chloramphenicol in treating typhoid fever of children in Africa. Percentage of relapse and carrier rates of patients treated with amoxycillin; Advantage of using amoxycillin with regard to clinical and temperature response; Correlation...

  • Amoxycillin in treatment of typhoid fever in patients with haematological contraindications to chloramphenicol. Afifi, A.M.; Adnan, M.; El Garf, A.A. // British Medical Journal;10/30/1976, Vol. 2 Issue 6043, p1033 

    Examines the effectiveness of amoxycillin in treating adults with typhoid fever in Egypt. Dosage for the administration of the drug; Potential of the medicine as alternative to chloramphenicol; Bacteriological response of patients treated with amoxycillin.

  • "Preliminary report of the beneficial effect of chloromycetin in the treatment of typhoid fever"--a commentary. Basnyat, Buddha // Wilderness & Environmental Medicine;Fall2004, Vol. 15 Issue 3, p216 

    Presents a commentary on the article "Preliminary Report on the Beneficial Effect of Chloromycetin in the treatment of Typhoid Fever," by T. E. Woodward, J. E. Smadel, H. L. Ley Jr., R. Green and D. S. Mankikar, which appeared in the 1948 issue of the "Annals of Internal Medicine." Reason why...

  • REDUCED MINIMUM INHIBITORY CONCENTRATION OF CHLORAMPHENICOL FOR SALMONELLA ENTERICA SEROVAR TYPHI. Mandal, S.; Mandal, M. D.; Pal, N. K. // Indian Journal of Medical Sciences;Jan2004, Vol. 58 Issue 1, p16 

    Ciprofloxacin replaced chloramphenicol (C), the best choice of antibiotic in the treatment of enteric fever, when C-resistant enteric fever emerged and caused outbreaks in different parts of the world. C-sensitive S. enterica serovar Typhi emerged again due to withdrawal of the antibiotic...

  • Excerpts from: PRELIMINARY REPORT ON THE BENEFICIAL EFFECT OF CHLOROMYCETIN IN THE TREATMENT OF TYPHOID FEVER. Woodward, Theodore E.; Smadel, Joseph E.; Ley Jr., Herbert L.; Green, Richard; Marlkikar, D. S. // Wilderness & Environmental Medicine;Fall2004, Vol. 15 Issue 3, p218 

    Presents excerpts from the article "Preliminary Report on the Beneficial Effect of Chloromycetin in the Treatment of Typhoid Fever," by Theodore E. Woodward, Joseph E. Smadel, Herbert L. Ley Jr., Richard Green, and D. S. Mankikar, published in the 1948 issue of the "Annals of Emergency Medicine."

  • Specimens and culture media for the laboratory diagnosis of typhoid fever. Wain, John; To Song Diep; Van Be Bay, Phan; Walsh, Amanda L.; Vinh, Ha; Duong, Nguyen M.; Vo Anh Ho; Hien, Tran T.; Farrar, Jeremy; White, Nicholas J.; Parry, Christopher M.; Day, Nicholas P. J. // Journal of Infection in Developing Countries;2008, Vol. 2 Issue 6, p469 

    Background: Culture of S. Typhi is necessary for the definitive diagnosis of typhoid fever and provides isolates for antibiotic susceptibility testing and epidemiological studies. However, current methods are not fully optimised and sourcing culture media and bottles for culture media may be...

  • Evaluation of false negativity of the Widal test among culture proven typhoid fever cases. Hosoglu, Salih; Boşnak, Vuslat; Akalin, Şerife; Geyik, Mehmet Faruk; Ayaz, Celal // Journal of Infection in Developing Countries;2008, Vol. 2 Issue 6, p475 

    Background: The Widal test is the most common, specific and quick diagnostic method available in the world for diagnosis of typhoid fever; however, false negativity is one of the obstructive features of the test. The aim of this study was to evaluate the associated factors with Widal test...

  • Diagnostic efficacy of Widal slide agglutination test against Widal tube agglutination test in enteric fever. Gaikwad, Ujjwala N.; Rajurkar, Monali // International Journal of Medicine & Public Health;Jul-Sep2014, Vol. 4 Issue 3, p227 

    Introduction: Enteric fever is an endemic disease in India and warrants rapid and affordable diagnosis. The Widal slide agglutination test is a commonly used rapid screening test for this purpose. The literature available on its diagnostic ability in comparison to the tube agglutination test is...

  • Quinolones in the Treatment of Typhoid Fever. Erdal Akalin, H. // Drugs;Dec1999 Supplement 2, Vol. 58 Issue 6, p52 

    Typhoid fever is a severe systemic disease. Treatment with appropriate antibiotics is essential for enteric fever. Development and rapid dissemination of resistance to chloramphenicol, ampicillin, and cotrimoxazole have complicated the treatment of enteric fever. Therapeutic options for the...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics