TITLE

SAFETY AND IMMUNOGENICITY OF THE INTRADERMAL THAI RED CROSS (2-2-2-0-1-1) POST EXPOSURE VACCINATION REGIMEN IN THE INDIAN POPULATION USING PURIFIED CHICK EMBRYO CELL RABIES VACCINE

AUTHOR(S)
Chhabra, M.; Ichhpujani, R. L.; Bhardwaj, M.; Tiwari, K. N.; Panda, R. C.; Lal, S.
PUB. DATE
January 2005
SOURCE
Indian Journal of Medical Microbiology;Jan2005, Vol. 23 Issue 1, p24
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Purpose: To test the immunogenicity of the WHO recommended "2-2-2-0-1-1" post-exposure rabies vaccination regimen in Indian subjects to determine the feasibility of replacing crude sheep brain nerve tissue rabies vaccine with modern tissue culture rabies vaccine at major anti-rabies treatment centers throughout India. Methods: Purified chick embryo cell vaccine (PCECV) was administered in the dosage of 0.1mL per site to 53 Indian subjects. Results: All subjects produced rabies antibodies above 0.5IU/mL by day 14 post-vaccination. Only minor adverse reactions including swelling (6.6%), erythema (5.4%) and pain (1.4%) were observed for which no treatment was required. Conclusions: This study demonstrated that PCECV is safe and highly immunogenic in Indian subjects when administered intradermally as 0.1mL/site using the "2-2-2-0-1-1" post-exposure regimen.
ACCESSION #
18078090

 

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