Risk for injury in the elderly may vary by benzodiazepine, independent of half-life

Gill, Sudeep S.; Rochon, Paula A.
July 2005
ACP Journal Club;Jul/Aug2005, Vol. 143 Issue 1, p55
Academic Journal
This article presents information on a study related to a 5-year prospective assessment of the risk associated with individual benzodiazepines and doses in new elderly users. The risk for injury with current use of benzodiazepines compared with nonuse periods in the same patient varied according to the type of benzodiazepine but did not correlate with half-life: Temazepam and oxazepam, lorazepam and flurazepam were associated with an increased risk for injuries. In older persons, risk for injury was increased with current use of benzodiazepines compared with nonuse periods for some benzodiazepines, a phenomenon explained in part by dose equivalents.


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